Evidence map›Paper›PMID 40731308›Full record

ArticleBritish journal of haematology2025

The importance of systemic inflammatory response measurements as pretransplant risk factors for outcome after allogeneic haematopoietic cell transplantation.

Hartmut Bertz, Jörg Sahlmann, Donald C McMillan, Claudia Wehr, Jesus Duque-Afonso, Kristina Maas-Bauer, Ralph Wäsch, Julia Nikolaychuk, Christine Greil, Jann Arends and 2 more

Abstract read
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hartmut BertzUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.ORCID https://orcid.org/0000-0002-3805-8123
Jörg SahlmannFaculty of Medicine, Institute of Medical Biometry and Statistics (IMBI), University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Donald C McMillanAcademic Unit of Surgery, School of Medicine Dentistry and Nursing, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Claudia WehrUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.
Jesus Duque-AfonsoUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.
Kristina Maas-BauerUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.
Ralph WäschUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.
Julia NikolaychukUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.
Christine GreilUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.
Jann ArendsUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.
Jürgen FinkeUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.
Robert ZeiserUniversity Medical Center, Department of Internal Medicine, Hematology, Oncology & Stem Cell Transplantation, Faculty of Medicine, Freiburg, Germany.ORCID https://orcid.org/0000-0001-6565-3393

Funding

Deutsche Forschungsgemeinschaft (DFG) 441891347European Research council (ERC) 101094168European Research council (ERC) 517204983
6 · The paper itself

Abstract

Systemic inflammatory response (SIR) measures are known prognostic values in patients with solid tumours. Little is known about their impact in haematological diseases or allogeneic haematopoietic cell transplantation (alloHCT). Therefore, we evaluate the association of pretransplant inflammatory markers with the clinical outcome in a prospective analysis of alloHCT. We included 2201 consecutive patients undergoing their first alloHCT. At admission, C-reactive protein (CRP), serum albumin (sALB), a composite inflammatory score (modified Glasgow prognostic score, mGPS) and the body mass index (BMI) were recorded. These, the EBMT score and the HCT-specific comorbidity index (HCT-CI) were statistically analysed for overall/progression-free survival (OS/PFS), non-relapse mortality (NRM), relapse and graft-versus-host disease (GvHD). CRP was increased in 34.8%, 17% had a low sALB, 2.9% an increased (≥35 kg/m

Indexed as

Hematopoietic Stem Cell TransplantationSystemic Inflammatory Response SyndromeAdolescentAdultAgedBiomarkersBody Mass IndexC-Reactive ProteinFemaleGraft vs Host DiseaseHumansMaleMiddle AgedPrognosisProspective StudiesRisk FactorsBiomarkersC-Reactive Proteinallogeneic haematopoietic stem cell transplantationmodified Glasgow prognostic scoreoutcomerisk factorssystemic inflammation response measures

Identifiers

PMID40731308
PMCPMC12512061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.