Evidence map›Paper›PMID 40732225›Full record

ReviewPharmaceuticals (Basel, Switzerland)2025

Regulation of L-Lactate in Glutamate Excitotoxicity Under Cerebral Ischemia: Pathophysiology and Preventive Strategy.

Mao Zhang, Yanyan Wang, Zili Gong, Wen Jiang, Guodong Ge, Hong Guo

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mao ZhangDepartment of Medical Genetics, College of Basic Medical Science, Army Medical University, 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038, China.
Yanyan WangDepartment of Medical Genetics, College of Basic Medical Science, Army Medical University, 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038, China.
Zili GongDepartment of Neurology, Xinqiao Hospital, Army Medical University, 83 Xinqiao Main Street, Shapingba District, Chongqing 400038, China.
Wen JiangDepartment of Medical Genetics, College of Basic Medical Science, Army Medical University, 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038, China.
Guodong GeDepartment of Medical Genetics, College of Basic Medical Science, Army Medical University, 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038, China.
Hong GuoDepartment of Medical Genetics, College of Basic Medical Science, Army Medical University, 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038, China.ORCID 0000-0002-3244-1340

Funding

Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX0558Science and Technology Research Project of Chongqing Education Commission KJQN202412808
6 · The paper itself

Abstract

Glutamate is an excitatory neurotransmitter in the central nervous system (CNS) that mediates synaptic transmission. However, glutamate homeostasis among neural cells is broken in cerebral ischemia. Excessive glutamate triggers

Indexed as

astroglial L-lactate-sensitive receptor (LLR)calcium overloadcerebral ischemiaglutamateL-lactate

Identifiers

PMID40732225
PMCPMC12300972

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.