ArticlePathogens (Basel, Switzerland)2025
Retrospective Review of Children Hospitalized for Epstein-Barr Virus-Related Infectious Mononucleosis.
Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Age-Dependent Clinical Patterns of Primary Epstein-Barr Virus Infection in Children: Insights for Diagnostic Accuracy.Pathogens (Basel, Switzerland) · 2026Article
- A routine blood parameter-based nomogram to predict prolonged fever in children with primary EBV infection.Frontiers in pediatrics · 2026Article
- Association between Epstein-Barr viral load and duration of hospitalization in pediatric infectious mononucleosis: a single-center retrospective study.Frontiers in medicine · 2026Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOur objective was to investigate the clinical characteristics, complications, and treatment outcomes of Epstein-Barr virus (EBV)-related infectious mononucleosis (IM) in children and to identify risk factors associated with prolonged fever and abnormal liver function.
methodsThis retrospective study included 3006 children admitted to Shenzhen Children's Hospital from May 2009 to April 2024 with suspected EBV-related IM. After excluding cases without etiological evidence and those with underlying diseases, 2660 cases were analyzed. Data on demographics, clinical manifestations, laboratory findings, complications, and treatment outcomes were collected. Logistic regression was used to identify risk factors for prolonged fever and abnormal liver function.
resultsAmong the 2660 confirmed cases, patients ranged from 8 months to 17 years of age, with a median age of 4 years and a male-to-female ratio of 1.46:1. Co-infections were identified in 369 (13.9%) patients, predominantly with Group A Streptococcus. Complications occurred in 560 (24.46%) of the 2289 patients without co-infections, with bronchitis being the most common (42.68%). Elevated ferritin and atypical lymphocyte percentage were associated with prolonged fever (
conclusionsSpecific laboratory markers such as ferritin, atypical lymphocyte percentage, LDH, and CD4% are important predictors of prolonged fever or liver dysfunction in EBV-IM. Our findings suggest that antiviral therapy may not be beneficial in uncomplicated cases and highlight the need for tailored treatment strategies to optimize patient outcomes.
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