Evidence map›Paper›PMID 40732912›Full record

ArticleNutrients2025

Exploratory Study on Microbiota and Immune Responses to Short-Term

Fernando Rivero-Pino, Maria José Castro, Paz Redondo Del Río, Eloina Gutierrez, Agustín Mayo-Iscar, Mercedes Nocito, Alfredo Corell

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fernando Rivero-PinoDepartment of Medical Biochemistry, Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0003-1326-7452
Maria José CastroDepartamento de Enfermería, Universidad de Valladolid, 47003 Valladolid, Spain.
Paz Redondo Del RíoDepartamento de Pediatría, Inmunología, Obstetricia-Ginecología, Nutrición-Bromatología, Universidad de Valladolid, 47005 Valladolid, Spain.ORCID 0000-0003-4260-2731
Eloina GutierrezDepartamento de Pediatría, Inmunología, Obstetricia-Ginecología, Nutrición-Bromatología, Universidad de Valladolid, 47005 Valladolid, Spain.
Agustín Mayo-IscarDepartamento de Estadística e Investigación Operativa & IMUVA, Universidad de Valladolid, 47011 Valladolid, Spain.ORCID 0000-0003-0951-6508
Mercedes NocitoInmunología, Hospital Clínico de Zaragoza, 50009 Zaragoza, Spain.
Alfredo CorellDepartment of Medical Biochemistry, Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0001-5797-7814

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe gut microbiota and immune system are interconnected, with targeted nutritional interventions offering potential to modulate immune function. This study aimed to evaluate the short-term immunomodulatory effects of

methodsA 15-day dietary intervention was conducted involving healthy adults. Nutritional status, dietary habits, and systemic immune biomarkers were assessed, alongside changes in gut microbiota composition.

resultsThe results revealed significant effects on both cellular and humoral immunity. Cellular immunity was enhanced through increased circulating B lymphocytes, absolute monocyte counts, and leukocyte numbers, alongside reduced eosinophil levels, potentially mitigating allergic responses. Humoral immunity was improved by elevated serum IgG1, IgG2, and IgG4 levels, enhancing defenses against pathogenic antigens, and increased serum complement proteins C3 and C4, supporting innate immunity. Microbiota analysis showed a reduction in

conclusionsA short-term intake of

Indexed as

Gastrointestinal MicrobiomeImmunity, CellularProbioticsAdultDietFemaleHealthy VolunteersHumansImmunity, HumoralImmunity, InnateImmunoglobulin GMaleMiddle AgedNutritional StatusYoung AdultImmunoglobulin GActimelgut microbiotaimmunomodulationL. paracasei

Identifiers

PMID40732912
PMCPMC12300870

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.