Evidence map›Paper›PMID 40732937›Full record

ArticleNutrients2025

Sea Cucumber Egg Oligopeptides Ameliorate Cognitive Impairments and Pathology of Alzheimer's Disease Through Regulating HDAC3 and BDNF/NT3 via the Microbiota-Gut-Brain Axis.

Guifeng Zhang, Yanjie Dou, Huiwen Xie, Dan Pu, Longxing Wang, Renjun Wang, Xiaofei Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guifeng ZhangKey Laboratory of Saccharide and Lipid Metabolism Research in Liaoning Province, College of Life and Health of Dalian University, Dalian 116622, China.
Yanjie DouKey Laboratory of Saccharide and Lipid Metabolism Research in Liaoning Province, College of Life and Health of Dalian University, Dalian 116622, China.
Huiwen XieKey Laboratory of Saccharide and Lipid Metabolism Research in Liaoning Province, College of Life and Health of Dalian University, Dalian 116622, China.
Dan PuKey Laboratory of Saccharide and Lipid Metabolism Research in Liaoning Province, College of Life and Health of Dalian University, Dalian 116622, China.
Longxing WangDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Renjun WangKey Laboratory of Saccharide and Lipid Metabolism Research in Liaoning Province, College of Life and Health of Dalian University, Dalian 116622, China.
Xiaofei HanKey Laboratory of Saccharide and Lipid Metabolism Research in Liaoning Province, College of Life and Health of Dalian University, Dalian 116622, China.

Funding

Dalian University DLUXK-2024-YB-006
6 · The paper itself

Abstract

backgroundOligopeptides from sea cucumber eggs (SCEPs) are rarely studied for their neuroprotective effects.

methodsTherefore, we prepared SCEPs via simulated gastrointestinal digestion and then administered them to an Alzheimer's disease (AD) mouse model via gavage. Behavior tests, gut-brain histopathology and fecal microbiota transplantation (FMT) experiments were conducted, and gut microbiota and metabolite short-chain fatty acids (SCFAs) were evaluated via 16sRNA gene sequencing and LC-MS.

resultsThe results showed that both the SCEP and FMT groups experienced improvements in the cognitive impairments of AD and showed reduced levels of Aβ, P-Tau, GFAP, and NFL in the brain, especially in the hippocampus. SCEP remodeled the gut microbiota, increasing the relative abundances of

conclusionsThis study provides a promising candidate for preventing AD and a reference for applying SCEP.

Indexed as

Alzheimer DiseaseBrain-Derived Neurotrophic FactorBrain-Gut AxisCognitive DysfunctionEggsGastrointestinal MicrobiomeHistone DeacetylasesOligopeptidesSea CucumbersAnimalsBrainDisease Models, AnimalFatty Acids, VolatileFecal Microbiota TransplantationFecesHistone Deacetylase 3Bdnf protein, mouseBrain-Derived Neurotrophic FactorFatty Acids, VolatileHistone Deacetylase 3Histone DeacetylasesNeuroprotective AgentsOligopeptidesAlzheimer’s diseasecognitive dysfunctiongut microbiotaneuropathologysea cucumber egg oligopeptides

Identifiers

PMID40732937
PMCPMC12298608

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.