Evidence map›Paper›PMID 40733585›Full record

ArticleViruses2025

Role of Common Fractalkine Receptor Variants with Chronic Hepatitis B Patients in Tunisia.

Imene Ben Dhifallah, Kaouther Ayouni, Zeineb Belaiba, Bacem AlaDdine Razgui, Sahar Trabelsi, Henda Touzi, Amel Sadraoui, Walid Hammemi, Hela Hannachi, Amira Kebir and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Imene Ben DhifallahLaboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.ORCID 0000-0002-2630-3339
Kaouther AyouniLaboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.ORCID 0000-0002-0872-5706
Zeineb BelaibaLaboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.ORCID 0000-0001-5187-0813
Bacem AlaDdine RazguiLaboratory of Bioinformatic, Biomathematics and Biostatistics, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Sahar TrabelsiLaboratory of Bioinformatic, Biomathematics and Biostatistics, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Henda TouziLaboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Amel SadraouiLaboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Walid HammemiLaboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Hela HannachiLaboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Amira KebirLaboratory of Bioinformatic, Biomathematics and Biostatistics, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Slimane Ben MiledLaboratory of Bioinformatic, Biomathematics and Biostatistics, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.ORCID 0000-0002-2390-4892
Henda TrikiLaboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.

Funding

Ministry of Higher Education and Scientific Research Research laboratory LR20IPT02
6 · The paper itself

Abstract

Chronic hepatitis B virus (CHB) infection remains a leading cause of hepatic inflammation and damage. Several studies have suggested the significant role of CX3C chemokine receptor 1 (CX3CR1) in inflammatory damages. The polymorphisms V249I and T280M affect receptor expression and function. In the current study, we investigated the association of V249I and T280M variants of the CX3CR1 fractalkine receptor with susceptibility to CHB disease. In total, 280 patients with chronic hepatitis B and 260 controls from different cities of Tunisia recruited in the Pasteur Institute of Tunisia between January 2017 and December 2022 were genotyped for the V249I and T280M CX3CR1 gene. The allele and genotype frequencies of these variants did not show significant associations with susceptibility to CHB infection (

Indexed as

CX3C Chemokine Receptor 1Genetic Predisposition to DiseaseHepatitis B, ChronicAdultAgedAllelesCase-Control StudiesFemaleGene FrequencyGenotypeHepatitis B virusHumansMaleMiddle AgedPolymorphism, GeneticPolymorphism, Single NucleotideCX3C Chemokine Receptor 1CX3CR1 protein, humanCHBCX3CR1FDRfractalkine receptorPCRpolymorphism

Identifiers

PMID40733585
PMCPMC12299179

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.