ArticleFrontiers in neurology2025
Differential analysis of clinical outcomes in cerebral infarction associated with REM-OSA and NREM-OSA: a retrospective database study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Impact of gender differences on prognosis in patients with acute cerebral infarction associated with REM-related obstructive sleep apnea: a retrospective cohort study.Frontiers in neurology · 2026Article
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8 authors.
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Abstract
Background: Obstructive sleep apnea (OSA) is one of the factors that affect the prognosis of cerebral infarction. Rapid eye movement-related obstructive sleep apnea (REM-OSA) has been confirmed as an important clinical subtype of OSA, yet it is frequently overlooked in clinical practice. REM-OSA is an important but underrecognized clinical issue in the study of improving the prognosis of cerebral infarction. Objective: To investigate the relationships among REM-OSA and cerebral infarction clinical prognosis. Methods: In this retrospective cohort study, 318 cerebral infarction patients with OSA (AHI ≥ 5) were enrolled from February 2022 to January 2025 at the Department of Neurology, Affiliated Hospital of Yangzhou University. Participants were stratified into REM-OSA ( Results: Compared to NREM-OSA, REM-OSA patients exhibited: (1) Poorer prognosis: Higher 3-month mRS scores (OR = 1.543, Conclusion: REM-OSA is independently associated with poorer prognosis in cerebral infarction patients. Potential explanatory mechanisms include REM-specific hypoxia, systemic inflammation, and basal ganglia vulnerability.
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