ArticleNeuropsychiatric disease and treatment2025
Influence of Polymorphisms in Gene SATB2 on Antipsychotics Response in Chinese Han Population.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Responses to antipsychotic drugs vary significantly among patients with schizophrenia. This study explored the correlation between rs1900327, rs7557687, rs733156, and rs6745135 in gene SATB2 and antipsychotics response in the Chinese Han population. Methods: This study included 228 patients with schizophrenia. The polymorphisms of SATB2 gene (rs1900327, rs7557687, rs733156, and rs6745135) in patients were measured using the KASP technique. During the study, patients received a single antipsychotic medication for a duration of eight weeks. The clinical efficacy was evaluated using the Positive and Negative Syndrome Scale (PANSS) scores. A patient with a decrease of at least 50% in the total PANSS score was categorized as a good responder, whereas those who did not meet this threshold were classified as poor responders. Results: Polymorphisms of rs1900327, rs7557687 and rs733156 were associated with the decrease in PANSS on week 8; however, this was no longer significant after Bonferroni correction ( Conclusion: The SATB2 gene polymorphisms were related to the effectiveness of antipsychotics in treating general psychopathological symptoms.
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