ReviewFrontiers in neuroscience2025
Modulating excitation/inhibition balance through transcranial electrical stimulation: physiological mechanisms in animal models.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Prenatal stress, excitatory-inhibitory imbalance, and ADHD risk: a hypothesis-driven perspective on psilocybin-induced neuroplasticity.Translational psychiatry · 2026Review
- Deep Brain Stimulation Induces Antidepressant Effects by Restoring High-Fidelity Communication in the BNST-NAc Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The balance between excitatory and inhibitory (E/I) activity is a fundamental property of neural circuits, ensuring precise information processing and preventing pathological states such as hyperexcitability or network silencing. Disruptions in this balance have been linked to several neurological and psychiatric disorders, including epilepsy, autism, and schizophrenia. Transcranial electrical stimulation (tES) can modulate the E/I balance through mechanisms that affect synaptic plasticity, neurotransmitter systems, and network synchronization. The main tES modalities-transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and transcranial random noise stimulation (tRNS)-operate through distinct physiological principles, enabling the modulation of neuronal excitability and oscillatory dynamics. Animal models offer controlled experimental conditions to study the effects of tES on E/I regulation at the cellular, synaptic, and network levels. Preclinical research has revealed polarity-dependent plasticity with tDCS, frequency-specific entrainment with tACS, and GABAergic modulation with tRNS. These findings are essential for validating computational models and refining stimulation protocols. Future studies should integrate multimodal technologies to enhance the translational relevance of tES and develop personalized neuromodulation strategies targeting E/I imbalance in brain disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.