ArticleWellcome open research2025
Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning.
Article in Wellcome open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Specialized RNA decay fine-tunes monogenic antigen expression in Trypanosoma brucei.Nature microbiology · 2026Article
- Kozak sequences regulate gene expression in Trypanosoma brucei.Nucleic acids research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Background: We recently described a pervasive cis-regulatory role for sequences in Methods: To address these questions, we applied machine learning to analyze existing transcriptome, TE, and proteomics data. Results: Our predictions indicate that both UTRs and codon usage bias impact gene expression in all three trypanosomatids, but with substantial differences. In Conclusions: Taken together, our findings indicate that gene expression control in trypanosomatids operates primarily at the point of translation, which is impacted by both UTRs and codon usage. We suggest a model whereby UTRs control the rate of translation initiation, while favoured codons increase the rate of translation elongation, thereby reducing mRNA turnover.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.