Evidence map›Paper›PMID 40735968›Full record

ArticleGut microbes2025

Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in

Niloofar Mirzadzare, Graham A D Blyth, Rita Hannawayya, Karina M Cirone, Geeta Kilari, Priyoshi Lahiri, Yi Lin Tan, Aydin Ivan Herik, Yongpeng Fu, Hayley Gorman and 3 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Endogenous cathelicidin protects againstInfection and immunity · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Niloofar MirzadzareFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Graham A D BlythFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Rita HannawayyaFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Karina M CironeFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Geeta KilariFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Priyoshi LahiriFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Yi Lin TanFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Aydin Ivan HerikFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Yongpeng FuFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
Hayley GormanMicrobiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Björn PetriMicrobiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Kris ChadeeMicrobiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.ORCID 0000-0003-2636-557X
Eduardo R CoboFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-5450-7673

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucus barrier during infections remains unclear. In this study, we used cathelicidin-deficient (

Indexed as

Antimicrobial Cationic PeptidesCathelicidinsCitrobacter rodentiumColitisEnterobacteriaceae InfectionsGoblet CellsMucusAnimalsColonHumansIntercellular Signaling Peptides and ProteinsIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutMucin-2Antimicrobial Cationic PeptidesCathelicidinsIntercellular Signaling Peptides and ProteinsMucin-2Reactive Oxygen SpeciesRetnlb protein, mouseTFF3 protein, humanTff3 protein, mouseTrefoil Factor-3cathelicidincitrobacter rodentiumColonic epitheliumgoblet cellsmucusreactive oxygen species

Identifiers

PMID40735968
PMCPMC12320862

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.