Evidence map›Paper›PMID 40735972›Full record

Trial reportDiabetes, obesity & metabolism2025

Effects of pioglitazone with and without exercise training on cardiorespiratory fitness and oxygen uptake kinetics in type 2 diabetes.

Eamonn O'Connor, Catherine Kiely, Norita Gildea, Donal O'Shea, Simon Green, Mikel Egaña

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eamonn O'ConnorSchool of Medicine, Department of Physiology, Trinity College Dublin, Dublin, Ireland.
Catherine KielySchool of Medicine, Department of Physiology, Trinity College Dublin, Dublin, Ireland.
Norita GildeaSchool of Medicine, Department of Physiology, Trinity College Dublin, Dublin, Ireland.
Donal O'SheaEndocrinology, St Columcille's and St Vincent's Hospitals, Dublin, Ireland.
Simon GreenSchool of Health Sciences, Western Sydney University, Sydney, Australia.
Mikel EgañaSchool of Medicine, Department of Physiology, Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0003-1984-9250

Funding

Research Ireland 08/RFP/BMT1342
6 · The paper itself

Abstract

aimsExercise tolerance is often impaired in type 2 diabetes (T2D), and barriers to regular exercise are common. This study evaluated whether 12 weeks of pioglitazone (PIO) therapy could enhance peak oxygen uptake (V̇O MATERIALS AND

methodsMale participants with T2D were assigned to one of the following groups: (1) non-exercising control (CON, n = 12), (2) PIO (15 mg/day) alone (PIO, n = 6), (3) exercise training alone (EXC, n = 13), or (4) PIO combined with exercise (PIO + EXC, n = 7). Exercise involved aerobic and resistance training three times per week for 12 weeks. V̇O

resultsPIO and PIO + EXC groups showed reductions (p < 0.01) in glycated haemoglobin (HbA

conclusionsAlthough PO improved glycaemic control, it did not enhance aerobic exercise capacity or V̇O

Indexed as

Cardiorespiratory FitnessDiabetes Mellitus, Type 2ExerciseExercise TherapyHypoglycemic AgentsOxygen ConsumptionPioglitazoneAgedCombined Modality TherapyExercise ToleranceGlycated HemoglobinHumansMaleMiddle AgedResistance TrainingGlycated HemoglobinHypoglycemic AgentsPioglitazonecardiac outputcardiovasculardiabetesoxygen uptake kineticsthiazolidinedione

Identifiers

PMID40735972
PMCPMC12409202

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.