Observational studyThe Journal of international medical research2025
A retrospective observational study on the prognostic role of inflammatory markers in futile recanalization after endovascular treatment for large-vessel stroke.
Observational study in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveEndovascular treatment has proven to be effective in improving the outcome of patients with large-vessel stroke. However, more than half of the patients experience poor outcomes despite successful recanalization, which was defined as futile recanalization. The present study aimed to identify the relationship between multiple inflammatory markers (before and after endovascular treatment) and futile recanalization.MethodsBetween November 2019 and September 2022, we retrospectively enrolled 456 patients according to the inclusion and exclusion criteria. Inflammatory variables, including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic immune-inflammation index, systemic inflammatory response index, systemic coagulation-inflammation index, and white blood cell count to mean platelet volume ratio, were collected.ResultsAmong the cohort of 456 patients, it was observed that 271 (59.4%) patients experienced futile recanalization. Univariate analysis revealed that patients with futile recanalization had higher neutrophil-to-lymphocyte ratio and systemic inflammatory response index but lower lymphocyte-to-monocyte ratio and systemic coagulation-inflammation index at admission compared with those without (p < 0.05). Additionally, at postoperation, patients with futile recanalization had higher neutrophil-to-lymphocyte ratio, systemic inflammatory response index, and systemic immune-inflammation index but lower lymphocyte-to-monocyte ratio and systemic coagulation-inflammation index compared with those without (p < 0.05). However, there were no significant differences in admission platelet-to-lymphocyte ratio, admission systemic immune-inflammation index, admission white blood cell count to mean platelet volume ratio, postoperation platelet-to-lymphocyte ratio, and postoperation white blood cell count to mean platelet volume ratio between the futile recanalization group and nonfutile recanalization group (p > 0.05). Furthermore, multivariate logistic regression analysis showed that only admission systemic inflammatory response index, postoperation neutrophil-to-lymphocyte ratio, postoperation systemic inflammatory response index, and postoperation systemic immune-inflammation index remained significantly correlated with futile recanalization (p < 0.05). Receiver operating characteristic curves revealed that postoperation neutrophil-to-lymphocyte ratio was the most predictive marker for futile recanalization (area under the curve = 0.623, 95% confidence interval: 0.572-0.675).ConclusionAdmission systemic inflammatory response index, postoperation neutrophil-to-lymphocyte ratio, postoperation systemic inflammatory response index, and postoperation systemic immune-inflammation index were independently associated with futile recanalization, and postoperation neutrophil-to-lymphocyte ratio may have the highest ability in predicting futile recanalization in patients who underwent endovascular treatment.
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