Evidence map›Paper›PMID 40736591›Full record

ArticleVeterinary research communications2025

Immune-antioxidant responses, autophagy, endoplasmic reticulum stress, resistance to Aeromonas sobria in Nile tilapia under arsenic exposure: The mitigating role of a genistein-fortified diet.

Badriyah S Alotaibi, Amany Abdel-Rahman Mohamed, Yasmina M Abd-Elhakim, Saed A Althobaiti, Shatha B Albattal, Mohamed Mohamed Soliman, Tarek Khamis, Mohamed M M Metwally, Nawal Alsubaie, Rowida E Ibrahim

Abstract read
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Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Badriyah S AlotaibiDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Amany Abdel-Rahman MohamedDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt. amanyrahman292@gmail.com.
Yasmina M Abd-ElhakimDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt. yasmina_forensic@hotmail.com.
Saed A AlthobaitiDepartment of Biology, Turabah University College, Taif University, P.O. Box 11099, Turabah, Taif, Saudi Arabia.
Shatha B AlbattalGeneral Science and English Language Department, College of Applied Sciences, AlMaarefa University, Riyadh, Saudi Arabia.
Mohamed Mohamed SolimanDepartment of Clinical Laboratory Sciences, Turabah University College, Taif University, Taif, Saudi Arabia.
Tarek KhamisDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt.
Mohamed M M MetwallyDepartment of Pathology, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt.
Nawal AlsubaieDepartment of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Rowida E IbrahimDepartment of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt. rowidakamhawey48@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune system of fish is severely impacted by heavy metal pollutants that enter the aquatic system, reducing their survival and resistance to diseases. Arsenic is a widespread heavy metal that contaminates aquatic bodies, impacts fish health, and hinders the sustainability of aquaculture. In the current investigation, we studied the arsenic-hazard consequences on the hematology, serum immunological responses, antioxidant activity, autophagy-related genes, splenic architecture, and protection against Aeromonas sobria in Nile tilapia (Oreochromis niloticus). Additionally, we proposed the ameliorative potential of genistein as a feed additive against arsenic exposure. For this purpose, 160 fish were equally set into four groups, each with four replicates for sixty days. The C (control) and GN (genistein) groups were fed basal diets fortified with 0 and 500 mg genistein/kg diet and were not exposed to arsenic. However, the AS (arsenic) and AS + GN (arsenic + genistein) groups were reared under arsenic conditions (10 µg/L of As

Indexed as

AntioxidantsArsenicCichlidsEndoplasmic Reticulum StressFish DiseasesGenisteinGram-Negative Bacterial InfectionsWater Pollutants, ChemicalAeromonasAnimal FeedAnimalsAutophagyDietDietary SupplementsAntioxidantsArsenicGenisteinWater Pollutants, ChemicalAeromonas sobriaArsenicEndoplasmic reticulum stressGenisteinNile tilapia

Identifiers

PMID40736591

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.