SynthesisNeuroradiology2025
Cortical venous opacification score predicts outcomes after thrombectomy in large vessel occlusion stroke: a systematic review and meta-analysis.
Synthesis in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Correlation Between Lateral Ventricle Asymmetry and Cerebral Blood Flow: Implications for Stroke Risk.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to assess whether the Cortical Vein Opacification Score (COVES), a visual scoring system based on single-phase Computed Tomography Angiography (CTA), is associated with clinical and radiological outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO) after endovascular treatment (EVT). METHODS AND MATERIALS: A systematic review and meta-analysis were conducted according to PRISMA guidelines. PubMed, EMBASE, and Cochrane Library were searched from inception to early June 2025, identifying 572 articles, of which 6 were included. Post-hoc analyses of randomized controlled trials (RCTs) and observational studies, with patients stratified by venous outflow (VO) status, were included. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed using I² statistic. Sensitivity analyses were performed in outcomes that presented high heterogeneity.
resultsThe six studies included 2,709 patients. VO + was associated with higher excellent (RR 1.34; p < 0.001) and successful reperfusion (RR 1.05; p = 0.001). Functional independence at 90 days (modified Rankin Scale [mRS] 0-2) was higher in the VO + group (RR 2.67; p = 0.002). VO + was associated with lower rates of symptomatic intracranial hemorrhage (sICH), parenchymal hematoma (PH), and mortality at 90 days.
conclusionVO + is associated with better reperfusion and functional independence, as well as reduced hemorrhagic complications and mortality. These findings support the potential prognostic value of VO in AIS-LVO patients undergoing EVT. Heterogeneity and limited number of studies warrant cautious interpretation. Standardized imaging protocols and prospective validation are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.