Evidence map›Paper›PMID 40736607›Full record

ArticleWorld journal of microbiology & biotechnology2025

Laminaria Japonica hydrolysate as a novel biostimulant for enhancing DHA accumulation in Aurantiochytrium limacinum.

Jia-Xue Lin, Ying Wang, Shao-Geng Zhao, Bei-Chen Huang, Yue Zhang, Zhi-Qiang Wang, Sheng-Jie Li, Qian Liu, Yan Ma, Jing-Run Ye and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jia-Xue Lin *School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Ying Wang *Department of Obstetrics and Gynecology, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Shandong University, Qingdao, Shandong, P.R. China.
Shao-Geng ZhaoSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Bei-Chen HuangSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Yue ZhangSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Zhi-Qiang WangSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Sheng-Jie LiSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Qian LiuSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Yan MaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Jing-Run YeSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China.
Hai-Ying WangKey Laboratory of Sustainable Development of Polar Fishery, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, China.
Zhi-Peng WangSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, Shandong Province, China. wangzpmbio@163.com.

Funding

Key research program of China National Tobacco Corporation No. 110202102018Natural Science Foundation of Shandong Province ZR2024MC053,ZR2020MC003Talent research Foundation of Qingdao Agricultural University 663/1120037, 663/1120036, 665/1120058
6 · The paper itself

Abstract

Aurantiochytrium limacinum is recognized as an ideal candidate to produce docosahexaenoic acid (DHA). However, elevating the biomass and lipid yield on a large scale is still a challenge. In this study, a simple and feasible strategy for enhancing DHA accumulation based on Laminaria japonica hydrolysate (LPH) addition has been developed. The addition of 40 mL/L LPH enhanced the accumulation of biomass and lipid of A. limacinum by 31.48% and 49.48%, respectively. Meanwhile, the DHA production was increased by 40.78%. By investigating the effects on DHA and biomass accumulation hormones in LPH, gibberellin 3, abscisic acid, and salicylic acid were characterized as the key factor. With the addition of LPH, the upregulated genes were enriched in pathways including fatty acid biosynthesis, metabolism, and the tricarboxylic acid cycle. In particular, key genes involved in fatty acid synthesis, such as ACC1 and FAS2, were significantly upregulated. In this study, LPH was identified as a novel additive with practical application value due to its readily available and low-cost raw ingredients.

Indexed as

Docosahexaenoic AcidsLaminariaStramenopilesAbscisic AcidBiomassEdible SeaweedsFatty AcidsGibberellinsHydrolysisLipid MetabolismSalicylic AcidAbscisic AcidDocosahexaenoic AcidsFatty AcidsGibberellinsSalicylic AcidAurantiochytrium limacinumBiomassLaminaria Japonica hydrolysatePlant hormones

Identifiers

PMID40736607

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.