Evidence map›Paper›PMID 40737407›Full record

ArticleScience advances2025

Magnetically induced magnetosome chain (MAGiC): A biogenic magnetic-particle-imaging tracer with high performance and navigability.

Lei Li, Chan Zhao, Zhiyuan Zhao, Dou Han, Yidong Liao, Yanjun Liu, Sijia Liu, Xiaohua Jia, Jiesheng Tian, Qing Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lei LiThe School of Life Science and Technology, Xidian University, Xi'an 710126, China.ORCID 0000-0001-5847-6923
Chan ZhaoState Key Laboratory of Animal Biotech Breeding and College of Biological Sciences, China Agricultural University, Beijing 100193, China.ORCID 0009-0000-1835-3937
Zhiyuan ZhaoWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.ORCID 0000-0002-6839-1189
Dou HanState Key Laboratory of Animal Biotech Breeding and College of Biological Sciences, China Agricultural University, Beijing 100193, China.ORCID 0009-0009-0163-8616
Yidong LiaoThe CAS Key Laboratory of Molecular Imaging and the Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Beijing 100190, China.ORCID 0000-0002-0495-4405
Yanjun LiuThe CAS Key Laboratory of Molecular Imaging and the Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Beijing 100190, China.ORCID 0000-0002-1706-8488
Sijia LiuThe CAS Key Laboratory of Molecular Imaging and the Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Beijing 100190, China.ORCID 0000-0002-0968-669X
Xiaohua JiaThe CAS Key Laboratory of Molecular Imaging and the Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Beijing 100190, China.ORCID 0000-0002-3748-9618
Jiesheng TianState Key Laboratory of Animal Biotech Breeding and College of Biological Sciences, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-2924-2428
Qing LiuInstitute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0003-2700-9956
Xin FengThe CAS Key Laboratory of Molecular Imaging and the Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Beijing 100190, China.ORCID 0000-0001-9506-8486
Jie TianThe School of Life Science and Technology, Xidian University, Xi'an 710126, China.ORCID 0000-0003-0498-0432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic particle imaging (MPI) enables real-time, sensitive, and quantitative visualization of tracer distribution, augmenting the capability of in vivo imaging technologies. Previous MPI tracer research has predominantly focused on superparamagnetic nanoparticles, whose suboptimal sigmoidal magnetization curves limit their spatial resolution. Here, we introduce the magnetically induced magnetosome chain (MAGiC), a superferromagnetic MPI tracer, demonstrating a 25-fold improvement in resolution in the excitation direction and an order of magnitude improvement in signal intensity compared to the commercial tracer VivoTrax+. Under a gradient field of 4 tesla per meter, the resolution in the excitation direction reached 80 micrometers. Furthermore, MAGiC can be accurately manipulated using magnetic fields, making it an MPI-trackable microrobot. We have elucidated the mechanisms underlying MAGiC's superior performance and validated its effectiveness in vitro and in vivo. As a high-performance MPI tracer and microrobot, MAGiC holds tremendous potential for various applications, such as cell tracking, image-guided drug delivery, and therapeutic interventions.

Indexed as

Magnetic Resonance ImagingMagnetite NanoparticlesMagnetosomesAnimalsContrast MediaHumansMiceContrast MediaMagnetite Nanoparticles

Identifiers

PMID40737407
PMCPMC12309696

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.