Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
20 authors.
Cuicui WangDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0009-0002-8825-2108
Liang FangDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0001-7809-5001
Meng ShiDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Xiangfeng NiuDepartment of Chemistry, Genetics, and Medicine, and Center for Mass Spectrometry and Metabolic Tracing, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0001-6723-7393
Tiandao LiDepartment of Developmental Biology, Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0003-1650-0555
Xiaofei LiDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Kevin ChoDepartment of Chemistry, Genetics, and Medicine, and Center for Mass Spectrometry and Metabolic Tracing, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-3041-3506
Yonghua HeDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Shuang LiuDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Aiwu LuDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Xiaoyun XingDepartment of Genetics, School of Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-1045-1775
Jessica LukowskiDepartment of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-0506-552X
Young Ah GooDepartment of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-8278-3621
John R SpeakmanCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.ORCID 0000-0002-2457-1823
Di ChenResearch Center for Computer-Aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.ORCID 0000-0002-4258-3457
Regis J O'KeefeDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0003-4055-0368
Gary J PattiDepartment of Chemistry, Genetics, and Medicine, and Center for Mass Spectrometry and Metabolic Tracing, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0002-3748-6193
Michael J ZuscikDepartment of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-0461-8708
Bo ZhangDepartment of Developmental Biology, Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0003-2962-5314
Jie ShenDepartment of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0003-4131-1211
Funding
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Developing Metabolomic Technologies to Advance Environmental Exposure AnalysisR35ES028365 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2017 to 2024
$5.9M
Studies on gut microbiome-joint connections in arthritisR01AR078414 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI GILL, STEVEN R., ZUSCIK, MICHAEL J · 2021 to 2025
$3.4M
Metabolic Regulation of Articular Cartilage and Joint HomeostasisR01AR079100 · NIAMS · WASHINGTON UNIVERSITY · PI O'KEEFE, REGIS J, SHEN, JIE · 2021 to 2025
$2.9M
Targeting angiogenesis for fracture nonunion treatment under inflammatory diseasesR01AR077616 · NIAMS · WASHINGTON UNIVERSITY · PI GUAN, JIANJUN, SHEN, JIE · 2020 to 2025
$2.7M
Epigenetic Regulation of Bone Regeneration in Inflammatory DiseaseR01AR075860 · NIAMS · WASHINGTON UNIVERSITY · PI SHEN, JIE · 2019 to 2024
$2.6M
Lipid Metabolism in Articular Cartilage and OA PathogenesisR01AR083900 · NIAMS · WASHINGTON UNIVERSITY · PI Jie Shen · 2024 to 2026
$1.9M
Transcriptional regulation of domesticated transposable elements-derived promoters in human genomeR35GM142917 · NIGMS · WASHINGTON UNIVERSITY · PI ZHANG, BO ABER · 2021 to 2025
$1.9M
Mechanisms of Physiologic and Pathologic OsteoclastogenesisR01AR072623 · NIAMS · WASHINGTON UNIVERSITY · PI ABU-AMER, YOUSEF · 2018 to 2022
$1.7M
Stem cell therapy for fracture nonunion under inflammatory diseasesR21AR077226 · NIAMS · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID, SHEN, JIE · 2020 to 2021
Osteoarthritis (OA) is a joint disease with an etiology partially rooted in metabolic dysfunction, yet the underlying mechanisms in this context are not determined, limiting opportunities to develop therapeutic treatments. In this study, we used a multiomic approach combining RNA sequencing, ATAC-seq, MRE-seq, and metabolomics to reveal that OA articular chondrocytes induced by imbalanced transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signaling have increased fatty acid synthesis and oxidation processes regulated by nuclear factor I A (NFIA) up-regulation. Inhibition of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis. · full record | Socratic