Evidence map›Paper›PMID 40738671›Full record

ArticleThe Journal of veterinary medical science2025

Treatment of portal vein thrombosis with rivaroxaban in an American cocker spaniel with chronic hepatitis: a case report.

Ryo Niijima, Takehiko Kakizaki, Chun-Ho Park, Satoshi Kameshima, Yuya Otaka, Hiroaki Kawaguchi

Abstract readCase Reports
In one paragraph

Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryo NiijimaKitasato University Veterinary Teaching Hospital, Aomori, Japan.
Takehiko KakizakiLaboratory of Veterinary Radiology and Radiation Biology, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Chun-Ho ParkLaboratory of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Satoshi KameshimaLaboratory of Small Animal Internal Medicine 1, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Yuya OtakaLaboratory of Small Animal Internal Medicine 2, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Hiroaki KawaguchiLaboratory of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, Aomori, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anticoagulants are commonly used to treat venous thrombosis. Rivaroxaban, a direct factor Xa inhibitor, is widely used in veterinary medicine to prevent and treat thromboembolism. It has been used to manage portal vein thrombosis (PVT) in humans. As the incidence of PVT with chronic hepatitis (CH) is low in dogs, treatment methods have not been fully established. This case report describes the treatment of a 9-year-old male American cocker spaniel with CH and ascites, possibly due to concurrent PVT, using rivaroxaban. During treatment with rivaroxaban and diuretics, the patient showed improvement in portal hypertension, ascites, and edema. Herein, we report the first case of using rivaroxaban for the management of PVT with CH (treated with glucocorticoids) in a dog.

Indexed as

Dog DiseasesFactor Xa InhibitorsHepatitis, ChronicPortal VeinRivaroxabanVenous ThrombosisAnimalsDogsMaleFactor Xa InhibitorsRivaroxabanchronic hepatitiscoagulationportal vein thrombosisrivaroxaban

Identifiers

PMID40738671
PMCPMC12417733

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.