Evidence map›Paper›PMID 40739082›Full record

ArticleJournal of neuro-oncology2025

Tumor control and motor function in patients with metastases located in the primary motor cortex after stereotactic radiosurgery.

Chris Z Wei, Hansen Deng, Eishan Ashwat, Luigi Albano, Diego Luy, Stephen Worrell, Constantinos G Hadjipanayis, Ajay Niranjan, L Dade Lunsford

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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chris Z WeiDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA, 15213, USA.
Hansen DengDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA, 15213, USA.
Eishan AshwatSchool of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Luigi AlbanoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA, 15213, USA.
Diego LuySchool of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Stephen WorrellSchool of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Constantinos G HadjipanayisDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA, 15213, USA.
Ajay NiranjanDepartment of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA, 15213, USA.
L Dade LunsfordCenter for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. lunsld@upmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo characterize the outcomes of patients with brain metastases located in the motor cortex after stereotactic radiosurgery (SRS).

methodsA retrospective review was performed of 1151 patients with brain metastases who underwent Gamma Knife SRS between 2012 and 2020. Outcome measures were motor function, radiographic changes, adverse radiation effect (ARE), disease-free progression, and overall survival time.

resultsIn total, 130 (11.3%) patients presented with 185 primary motor cortex tumors. Non-small cell lung cancer and breast cancer were the most common primary malignancies. The median age at SRS was 63 years, and 91 (70%) patients were female. The median tumor volume was 0.07 cm

conclusionsSRS provided effective and safe tumor control in patients with metastases located in the motor cortex including patients with peritumoral edema. Contralateral motor function was stabilized or improved in most patients, though the median follow-up of 9.4 months limits long-term interpretation.

Indexed as

Brain NeoplasmsMotor CortexRadiosurgeryAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesBrain metastasesMotor cortexStereotactic radiosurgery

Identifiers

PMID40739082

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.