ArticleNature2025
Diffusing protein binders to intrinsically disordered proteins.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Beyond the structure-function paradigm: A comprehensive review of intrinsically disordered proteins.Biochemistry and biophysics reports · 2026Review
- RINAMI: Residue-attributed interpretable neural network for predicting absolute folding free energy by merging structure and sequence information.Protein science : a publication of the Protein Society · 2026Article
- AI-discovered protein fragments as generalizable regulators of biomolecular condensates.bioRxiv : the preprint server for biology · 2026Article
- What will be the future of computational biology for macromolecules in the era of AI?PLoS computational biology · 2026Article
- Chemical adaptation: bridging synthetic chemistry with drug development.Science China. Life sciences · 2026Review
- Targeting the Undruggable: Deep Learning-Driven Design of Peptide Therapeutics in Cancer.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Modular Input-Output Biosensor Design UsingACS sensors · 2026Article
- Beyond Fungitoxicity: Recent Achievements in Targeted Fungicide Discovery.Journal of fungi (Basel, Switzerland) · 2026Review
- Tools For Building Artificial Biological Nanostructures.ACS nano · 2026Review
- amyloid-predict and LLPS-predict: Predicting phase separation propensities in the intrinsically disordered proteome.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sketching microprotein portraits.Protein science : a publication of the Protein Society · 2026Review
- Protein design and RNA design: Perspectives.Quantitative biology (Beijing, China) · 2026Article
- Use of hydrogen deuterium exchange mass spectrometry in tandem with modern structural biology.The Biochemical journal · 2026Review
- Protein foundation models: a comprehensive survey.Science China. Life sciences · 2026Review
- Generative Protein Design: From Deep Learning Algorithms to Translational Applications.International journal of molecular sciences · 2026Review
- Artificial allosteric protein switches with machine-learning-designed receptors.Nature biotechnology · 2026Article
- Intrinsic Disorder as a Biomimetic Design Paradigm.Biomimetics (Basel, Switzerland) · 2026Article
- Review
- De novo design of Ras isoform selective binders.Cell chemical biology · 2026Article
- The Art of Domesticating Proteins: How Cancer Cells Adapt to Therapeutic and Environmental Stressors.International journal of molecular sciences · 2026Review
Corrections and comments
- Update of
Authors and funding
32 authors.
Caixuan Liu *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1954-0731
Kejia Wu *Department of Biochemistry, University of Washington, Seattle, WA, USA. kejiawu@uw.edu.ORCID 0000-0002-4532-4290
Hojun Choi *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8657-9548
Hannah L HanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4787-5168
Xueli ZhangKey Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Joseph L WatsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Green AhnDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Jason Z ZhangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Sara ShijoDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Lydia L GoodCentre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5308-8542
Charlotte M FischerCentre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9473-2912
Alex KangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5487-0499
Evans BrackenbroughDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Brian CoventryDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6910-6255
Derrick R HickDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2950-1848
Seema QamarCentre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.
Xinting LiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Justin DecarreauDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Stacey R GerbenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Wei YangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Inna GoreshnikDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Dionne VafeadosInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2560-8907
Xinru WangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5994-707X
Mila LambDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Analisa MurrayDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1560-6673
Sebastian KennyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Magnus S BauerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Andrew N HoofnagleDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6449-0243
Ping ZhuKey Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0003-2648-3170
Tuomas P J KnowlesCentre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7879-0140
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID 0000-0001-7896-6217
Funding
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · 1986 to 2025
$12.6MNIDDK NIH HHS P30 DK017047
Abstract
Proteins that bind to intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) with high affinity and specificity could be useful for therapeutic and diagnostic applications
Indexed as
Intrinsically Disordered ProteinsAmyloidHumansIslet Amyloid PolypeptideLysosomesModels, MolecularPrion ProteinsProtein BindingRNA Recognition Motif ProteinsAmyloidIntrinsically Disordered ProteinsIslet Amyloid PolypeptidePrion ProteinsRNA Recognition Motif Proteins
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.