Evidence map›Paper›PMID 40739345›Full record

ArticleNature2025

A hypothalamic circuit that modulates feeding and parenting behaviours.

Ivan C Alcantara, Chia Li, Claire Gao, Shakira Rodriguez González, Laura E Mickelsen, Brian N Papas, Abigail I Goldschmidt, Isabel M Cohen, Christopher M Mazzone, Isabel de Araujo Salgado and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Paternal behavior is controlled by preoptic Trpc5 neurons.bioRxiv : the preprint server for biology · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Neural plasticity supporting parental behaviors.Current opinion in neurobiology · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Ivan C AlcantaraDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0987-2118
Chia LiDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Claire GaoDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8832-5103
Shakira Rodriguez GonzálezDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Laura E MickelsenDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Brian N PapasBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.ORCID 0000-0003-4540-1142
Abigail I GoldschmidtDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Isabel M CohenDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Christopher M MazzoneNational Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
Isabel de Araujo SalgadoDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9354-7042
Ramón A PiñolDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8877-8444
Cuiying XiaoDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Eva O KarolczakDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Jian-Liang LiBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.ORCID 0000-0002-6487-081X
Guohong CuiNational Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.ORCID 0000-0002-4555-028X
Marc L ReitmanDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0426-9475
Michael J KrashesDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. michael.krashes@nih.gov.ORCID 0000-0003-0966-3401

Funding

Epigenomics and DNA SequencingZICES102545 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WADE, PAUL A · 2012 to 2025
$27.4M
Probing neural circuits underlying satietyZIADK075087 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7M
Investigating addictive/compulsive feeding behaviorZIADK075088 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7M
Intramural NIH HHS ZIA DK075087Intramural NIH HHS ZIA DK075088Intramural NIH HHS ZIC ES102545
6 · The paper itself

Abstract

Across mammalian species, new mothers undergo behavioural changes to nurture their offspring and meet the caloric demands of milk production

Indexed as

Feeding BehaviorHypothalamusMaternal BehaviorNeural PathwaysAgouti-Related ProteinAnimalsAppetiteArcuate Nucleus of HypothalamusFemaleFood DeprivationGene Expression ProfilingHungerLactationMaleMiceNeuronsAgouti-Related Protein

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.