Evidence map›Paper›PMID 40739351›Full record

ArticleNature2025

Programmable protein ligation on cell surfaces.

Christian Kofoed, Girum Erkalo, Nicholas E S Tay, Xuanjia Ye, Yutong Lin, Tom W Muir

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Intelligent Programmable Membrane Nanosponge for Early Virus Blocking.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.Chembiochem : a European journal of chemical biology · 2026
    Review
  3. Review
  4. AbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Precision Labeling of Native Antibodies with Lock Coupling.Journal of the American Chemical Society · 2026
    Article
  12. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christian KofoedDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-8258-5887
Girum Erkalo *Department of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0009-0006-9337-2277
Nicholas E S Tay *Department of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-4063-8880
Xuanjia YeDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-6277-6045
Yutong LinDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Tom W MuirDepartment of Chemistry, Princeton University, Princeton, NJ, USA. muir@princeton.edu.ORCID 0000-0001-9635-0344

Funding

Structure, Function and Applications of InteinsR01GM086868 · NIGMS · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2008 to 2025
$4.4M
BD FACSymphony A3: A multi-laser analytical flow cytometer for the Princeton University Flow Cytometry Resource FacilityS10OD028592 · OD · PRINCETON UNIVERSITY · PI DECOSTE, CHRISTINA J. · 2021 to 2021
$400k
New Proximity Labeling Tools for Studying 3D Chromatin Structure and FunctionF32GM149123 · NIGMS · PRINCETON UNIVERSITY · PI TAY, NICHOLAS ENG SOON · 2023 to 2025
$233k
NIGMS NIH HHS F32 GM149123NIGMS NIH HHS R01 GM086868NIH HHS S10 OD028592
6 · The paper itself

Abstract

The surface landscapes of cells differ as a function of cell type and are frequently altered in disease contexts

Indexed as

Cell MembraneProtein EngineeringProtein SplicingAnimalsHumans

Identifiers

PMID40739351
PMCPMC12321220

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.