Trial reportBMC anesthesiology2025
The effect of isoflurane versus propofol-based total intravenous anesthesia on hemodynamic stability, intraoperative blood loss, surgical field quality, recovery characteristics, and complications in patients undergoing posterior lumbar fusion surgery: a randomized clinical trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Results and Future Perspectives of the Sustainable Anesthesia Project: A Large-Scale, Real-World Implementation Study at the Largest Spanish Private Healthcare Provider.Healthcare (Basel, Switzerland) · 2026Article
- Comparative evaluation of total intravenous anaesthesia versus inhalational anaesthesia on postoperative recovery in elective abdominal surgery.Bioinformation · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGeneral anesthesia is commonly used for spinal surgeries, achieved through inhalational methods or total intravenous anesthesia (TIVA). This study compared propofol-based TIVA with isoflurane anesthesia in patients undergoing posterior lumbar fusion surgery. Primary outcomes - intraoperative blood loss, surgical field quality, and hemodynamic stability - were selected for their direct impact on patient safety and surgical outcomes. Secondary outcomes evaluated recovery characteristics (extubation time, eye-opening, response to commands, and post-anesthesia recovery quality) and postoperative complications (PONV, pain scores).
methodsThis randomized clinical trial was conducted in Iran from 2024 to 2025. A total of sixty-six patients were randomly assigned to two groups-Isoflurane and TIVA-using a convenience sampling method. Hemodynamic changes and surgical field quality (Boezaart score) were recorded during the surgery. The recovery characteristics were recorded, including recovery times, and quality of recovery (assessed using the QoR-40 questionnaire). Additionally, complications such as postoperative nausea and vomiting (evaluated using the RINVR questionnaire), blood loss, and pain levels (measured by the Visual Analog Scale [VAS]) were assessed.
resultsThe TIVA group significantly reduced intraoperative blood loss and improved surgical field quality. Recovery times, including extubation, eye-opening, and response to verbal commands, were significantly shorter in the TIVA group. The quality of recovery was significantly higher in the TIVA group on the first and second postoperative days. No significant differences between the two groups were observed in hemodynamic stability or the incidence of Postoperative nausea and vomiting (PONV). Postoperative pain scores did not differ significantly, although TIVA patients reported higher pain immediately after surgery.
conclusionPropofol-based TIVA may benefit patients undergoing spinal fusion surgery due to reduced blood loss, improved surgical field quality, and faster recovery. However, further research is needed on its effects on hemodynamic stability, pain management, PONV, and long-term outcomes.
trial registrationThis study was registered with the Iranian Clinical Trials Registry under the code IRCT20230208057358N2 on 2024-08-13.
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