Evidence map›Paper›PMID 40740688›Full record

ReviewBurns & trauma2025

Innovations in hydrogel therapies for diabetic wound healing: bridging the gap between pathophysiology and clinical application.

Yao Wang, Haoming Wu, Yan Pan, Yibo Xiao, Yingying Chen, Shuhao Yang, Jun Wang, Wanyue Feng, Cheng Hu, Xiangke Niu and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yao WangClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081, China.
Haoming WuSchool of preclinical medicine of Chengdu University, Chengdu University, No. 2025 Chengluo Avenue, Sichuan, Chengdu 610106, China.
Yan PanClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081, China.
Yibo XiaoClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081, China.
Yingying ChenClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081, China.
Shuhao YangDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China.
Jun WangDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China.
Wanyue FengClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081, China.
Cheng HuNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Med-X Center for Materials, Sichuan University, No. 24, South Section of 1st Ring Road, Sichuan, Chengdu 610065, China.
Xiangke NiuClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081, China.
Xin YongKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, No. 20, Section 3, Renmin South Road, Sichuan, Chengdu 610041, China.
Jin YangClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081, China.
Xulin HuClinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wounds (DWs), which are complex and challenging to treat due to delayed healing and incomplete regeneration, pose a significant burden on global healthcare systems. Existing clinical interventions, which mainly comprise debridement, decompression, and wound dressings, have limited efficacy. In addition, DW pathogenesis is complex, with diabetic peripheral neuropathy, diabetic peripheral arterial disease, and diabetic foot infections further complicating wound management. Owing to their unique versatility, tunability, and hydrophilicity, hydrogels show promise in several biomedical applications, including DW management. They can effectively promote DW healing by loading therapeutic substances for on-demand release. Given the distinct physiological milieu of DWs, hydrogels with tailored attributes can be engineered to enable on-demand drug release, optimize the wound microenvironment, and cater to the diverse stages of wound healing. Based on the clinical status and pathophysiological features of DWs, this review explores hydrogel wound dressings with the following effects: hypoglycemic, nerve regeneration, vascular regeneration, anti-infective, and bone repair. Additionally, the strategy for applying hydrogels to DWs has been comprehensively studied to provide a robust theoretical foundation for DW treatment and pave the way for clinical translation.

Indexed as

BiomaterialsDiabetic woundsHydrogelsRegenerative medicineWound healing

Identifiers

PMID40740688
PMCPMC12309386

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.