ArticleFrontiers in neurology2025
Impact of thrombolytic therapy on basilar artery occlusion patients with atrial fibrillation: results from a multi-center prospective cohort study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
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8 authors.
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Abstract
Background: The benefits and risks of intravenous thrombolysis combined with endovascular treatment for basilar artery occlusion patients with atrial fibrillation (AF) are uncertain. This research investigates the disparities in the impact of bridging thrombolysis on the long-term prognoses of endovascular treatment between patients with AF and those without it. Methods: We analyzed data from a Chinese multi-center prospective registry conducted between March 2017 and February 2023. Primary analysis included favorable (mRS 0-2) and good (mRS 0-3) outcomes at 3 months, the risk ratio (aOR) and 95% confidence interval for the outcome associated with bridging thrombolysis were calculated using multivariate regression analysis. Subgroup analyses evaluated the relative excess risk index (REPI) for AF and intravenous thrombolysis. Results: Among 1,368 patients, the ratio of AF to non-AF patients was 434:934, the proportion receiving intravenous thrombolysis was 101 vs. 226. In the AF group, thrombolysis improved functional prognosis (aOR 1.93, 95% CI 1.14 to 3.29, Conclusion: The presence of AF modified the treatment effect of bridging thrombolysis in basilar artery occlusion. These findings warrant confirmation through RCT studies.
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