ArticleWorld journal of cardiology2025
Risk factors and predictive model for mortality in acute myocardial infarction with ventricular septal rupture at high altitudes.
Article in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- ATP-P2X7R-NLRP3 Axis as a Unifying Mechanism of ATP-Induced Cell Death in Degenerative Bone and Cardiovascular Diseases.Journal of inflammation research · 2026Review
- Cardiac Function Transition in Patients with Chronic Kidney Disease Undergoing Maintenance Hemodialysis in a High-Altitude Multi-Ethnic Region: A Comparative Study Between Yi and Non-Yi Ethnic Groups.Journal of inflammation research · 2026Article
- Mortality prediction in ventricular septal rupture at high altitude: A novel tool for resource-limited regions.World journal of cardiology · 2025Article
- Pyroptosis in cardiovascular diseases: molecular mechanisms, pathological roles, and therapeutic implications.American journal of cardiovascular disease · 2025Review
- Ubiquitination-mediated protein homeostasis in cardiovascular diseases: molecular mechanisms and therapeutic opportunities.American journal of cardiovascular disease · 2025Review
- Ferroptosis in ischemia-reperfusion injury: molecular mechanisms and therapeutic strategies.American journal of cardiovascular disease · 2025Review
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Authors and funding
11 authors.
Funding
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Abstract
backgroundAcute myocardial infarction (AMI) combined with ventricular septal perforation (VSR) is still a highly fatal condition in the era of reperfusion therapy. The incidence rate has decreased to 0.2%-0.4% due to the popularization of percutaneous coronary intervention. However, the risk is significantly increased for those who fail to undergo revascularization in time, and the mortality rate remains high. The current core contradiction in clinical practice lies in the selection of surgical timing, and the disparity in medical resources significantly affects prognosis. There is an urgent need to optimize the identification of high-risk populations and individualized treatment strategies.
aimTo investigate the clinical features, determine the prognostic factors, and develop a predictive model for 30-day mortality in patients with acute myocardial infarction complicated by ventricular septal rupture (AMI-VSR) residing in high-altitude regions.
methodsThis study retrospectively analyzed 48 AMI-VSR patients admitted to a Yunnan hospital from 2017 to 2024, with the establishment of survival (
resultsAge, uric acid (UA), interleukin-6 (IL-6), and low hemoglobin (Hb) were independent risk factors for 30-day mortality (odds ratios: 1.147, 1.006, 1.034, and 0.941, respectively;
conclusionThis study highlights age, UA, IL-6, and Hb as critical predictors of mortality in AMI-VSR patients at high altitudes. The validated nomogram provides a practical tool for early risk stratification and tailored interventions, addressing gaps in managing this high-risk population in resource-limited settings.
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