ReviewWorld journal of clinical oncology2025
Extracellular vesicles circular RNA: A new perspective and clinical application potential for mediating chemoresistance in colorectal cancer.
Review in World journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exosomal CeRNAs from the tumor microenvironment: hidden drivers of colorectal cancer progression.Journal of molecular histology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is a common and deadly malignancy worldwide, causing high morbidity and mortality rates. Chemoresistance continues to be the major barrier to the effective treatment of CRC. Circular RNA (circRNA), a recently identified class of non-coding RNA, has become an emerging focus in CRC research due to its abundant presence and stability in extracellular vesicles (EVs). The circRNA of EVs (EVs-circRNA) is closely associated with CRC progression and plays a pivotal role in chemoresistance mechanisms. This paper investigates the circRNA mechanism underlying different chemoresistance scenarios in CRC and explores the dual role of EVs-circRNA in mediating chemotherapy resistance. Furthermore, EVs-circRNA, a non-invasive biomarker for liquid biopsies, holds significant promise in clinical applications, ranging from early CRC diagnosis to monitoring disease progression and assessing prognosis. These studies provide a new perspective for uncovering CRC pathogenesis and lay the foundation for precision therapy and personalized treatment strategies for CRC. In the future, therapeutic strategies targeting EVs-circRNAs are anticipated to revolutionize CRC treatment, leading to improved therapeutic outcomes and enhanced quality of life for patients.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.