ArticleArchives of medical science : AMS2025
Pro-inflammatory and anti-inflammatory cytokines as candidate markers in the diagnosis and assessment of Crohn's disease activity.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: We evaluated the diagnostic characteristics of interleukin (IL)-12, interferon (IFN)-γ, IL-10 and IL-19 in the diagnosis and assessment of Crohn's disease (CD) activity. Material and methods: We studied 49 CD patients assigned to the active (33 patients) and inactive (16 patients) disease subgroups and 31 healthy controls. Serum cytokines were measured using ELISA. Cytokine levels and their multiplication results were compared between the groups and their diagnostic characteristics were assessed. Results: The levels of the studied cytokines except IL-10 and their multiplication results were significantly higher in CD patients than in controls ( Conclusions: Serum IFN-γ, IL-19 and some of the results of the studied cytokine levels' multiplication showed promising diagnostic performance in the diagnosis of CD and its active form, which requires further validation.
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