Evidence map›Paper›PMID 40741345›Full record

ArticleJournal of oral biology and craniofacial research

Phytochemicals profile, cellular viabillity and platelet activity of

Liska Barus, Coen Pramono Danudiningrat, Andra Rizqiawan, R Aries Muharram, I Gusti Putra Swabuana Purwoyudho, Dewa Gede Raka Satria Wibawa, Annisa Tri Maharani, Namira Rizqi Hayyinah, Alexander Patera Nugraha, Ahmad K M Humidat and 1 more

Abstract read
In one paragraph

Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Natural polymers in diabetes management: formulation prospects ofFrontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liska BarusDoctoral Study Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Coen Pramono DanudiningratOral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Andra RizqiawanOral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
R Aries MuharramOral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
I Gusti Putra Swabuana PurwoyudhoOral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Dewa Gede Raka Satria WibawaOral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Annisa Tri MaharaniDentistry Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Namira Rizqi HayyinahDentistry Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Alexander Patera NugrahaOrthodontic Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ahmad K M HumidatOral and Maxillofacial Surgery Department, Faculty of Dentistry, Al-Quds University, Jerusalem, Palestine.
Ni Putu Mira SumartaOral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: to investigates the phytochemical content of Methods: The cytotoxicity of the leaf extract was evaluated using fibroblast cells, with various concentrations of the extract. The platelet activity of the HrsL, was assessed by treating blood and analysing the concentration of P-selectin and platelet aggregation with the agonists epinephrine, ADP, and collagen, compared to blood without extract treatment as a control. Results: The Conclusion: HrsL non-toxic at low concentrations and increases platelet P-selectin, It does not decrease platelet aggregation with the epinephrine agonist at 7.8 mg/mL, but it reduces aggregation at concentrations above 7.8 mg/mL. It does not decrease platelet aggregation with the ADP and collagen agonists at concentrations less than or equal to 62.5 mg/mL, but reduces aggregation at concentrations above 62.5 mg/mL.

Indexed as

Hemostasis processHibiscus rosa-Sinensis Linn.Local hemostatic agentMedicinesWound healing

Identifiers

PMID40741345
PMCPMC12308018

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.