Evidence map›Paper›PMID 40743330›Full record

ArticleScience (New York, N.Y.)2025

Conserved noncoding cis elements associated with hibernation modulate metabolic and behavioral adaptations in mice.

Susan Steinwand, Cornelia Stacher Hörndli, Elliott Ferris, Jared Emery, Josue D Gonzalez Murcia, Adriana Cristina Rodriguez, Riley J Spotswood, Amandine Chaix, Alun Thomas, Crystal Davey and 1 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026
    Review
  4. Genomic-microbial coevolution in human development: chromosome 2 fusion, and human accelerated regions.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Susan Steinwand *Department of Neurobiology, University of Utah, Salt Lake City, UT, USA.ORCID 0009-0009-7654-5545
Cornelia Stacher Hörndli *Department of Neurobiology, University of Utah, Salt Lake City, UT, USA.ORCID 0009-0002-7804-5455
Elliott FerrisDepartment of Neurobiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-7379-1403
Jared EmeryDepartment of Neurobiology, University of Utah, Salt Lake City, UT, USA.
Josue D Gonzalez MurciaDepartment of Neurobiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-2951-8316
Adriana Cristina RodriguezDepartment of Neurobiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-6179-7234
Riley J SpotswoodDepartment of Neurobiology, University of Utah, Salt Lake City, UT, USA.
Amandine ChaixDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-7007-197X
Alun ThomasDivision of Epidemiology, University of Utah, Salt Lake City, UT, USA.
Crystal DaveyMutation Generation & Detection Core Facility, University of Utah, Salt Lake City, UT, USA.ORCID 0009-0002-6937-2577
Christopher GreggDepartment of Neurobiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-0819-1174

Funding

The Nature and Function of Genomic Imprinting in Monoaminergic NeuronsR01MH109577 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GREGG, CHRISTOPHER · 2016 to 2025
$5.6M
Gene regulatory mechanisms connecting metabolism and Alzheimer’s DiseaseRF1AG077201 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Christopher Gregg · 2023 to 2026
$3.8M
Training Program in Genomic MedicineT32HG008962 · NHGRI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Lynn Jorde, Aaron R Quinlan · 2016 to 2026
$3.0M
Mechanisms by which time-restricted feeding (TRF) delays the onset of age-related declines in health, cognition, and circadian rhythmsR01AG065993 · NIA · UNIVERSITY OF UTAH · PI CHAIX, AMANDINE H. · 2019 to 2023
$2.1M
Noncoding Elements Shaping Brain AgingR01AG064013 · NIA · UNIVERSITY OF UTAH · PI GREGG, CHRIS · 2019 to 2023
$1.9M
NHGRI NIH HHS T32 HG008962NIA NIH HHS R01 AG064013NIA NIH HHS R01 AG065993NIA NIH HHS RF1 AG077201NIMH NIH HHS R01 MH109577
6 · The paper itself

Abstract

Cis

Indexed as

Adaptation, PhysiologicalEnergy MetabolismHibernationAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsBehavior, AnimalConserved SequenceFemaleGene Expression RegulationHomeodomain ProteinsMaleMiceMice, KnockoutObesityRegulatory Sequences, Nucleic AcidTorporAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, mouseHomeodomain ProteinsTranscription Factors

Identifiers

PMID40743330
PMCPMC12403242

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.