Evidence mapPaperPMID 40743522Full record

ArticleJournal of medical Internet research2025

Advancing the Integration of Digital Health Technologies in the Drug Development Ecosystem.

Sakshi Sardar, Cheryl D Coon, Scottie Kern, Huong Huynh, Diane Stephenson, Joshua Rubin Abrams, Grace V Lee, Cecile Ollivier, Joseph A Hedrick, Martijn Ltm Müller and 5 more

Abstract read
In one paragraph

Article in Journal of medical Internet research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sakshi SardarCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0000-0001-5527-0217
Cheryl D CoonCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0000-0003-1585-2786
Scottie KernCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0000-0003-0135-6466
Huong HuynhCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0009-0008-7218-0406
Diane StephensonCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0000-0002-4262-436X
Joshua Rubin AbramsCritical Path Institute, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-9171-6458
Grace V LeeCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0009-0003-3907-8139
Cecile OllivierCritical Path Institute, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-7315-1104
Joseph A HedrickCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0000-0003-1629-4907
Martijn Ltm MüllerCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0000-0002-1133-7202
Luc J W EversCenter of Expertise for Parkinson and Movement Disorders, Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-8241-5087
Lada LeyensTakeda, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-7622-7004
Collin HovingaCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0009-0003-1447-029X
Shu Chin MaCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0009-0002-0343-1861
Klaus RomeroCritical Path Institute, Tucson, AZ, United States.ORCID https://orcid.org/0000-0002-8576-8638

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optimized frameworks for efficient and scalable deployment of digital health technologies (DHT) are needed to address existing bottlenecks and unlock the opportunities for remote monitoring and operationalizing decentralized trials. DHTs offer immense potential opportunities for transformation in drug development by providing remote, high frequency, longitudinal insights into physiological processes, and how participants feel and function. Currently, DHT-based drug development tool-related efforts have yielded valuable insights into effective practices and areas that need improvement. However, the development of the required infrastructure is a resource-intensive task, and its efficiency can be greatly enhanced by systematically identifying the required components and aligning them in ways that will avoid trial-and-error approaches by various stakeholders. In this perspective paper, we aim to highlight these crucial aspects required for supporting the rapid and large-scale deployment of DHTs. We propose the development of various standardized consensus frameworks to clearly lay out processes for various stakeholders and facilitate the seamless integration of the next generation of health care-sensing technologies into drug development.

Indexed as

Biomedical TechnologyDigital TechnologyDrug DevelopmentDigital HealthHumansTelemedicineclinical researchDHTdigital healthdigital health technologiesdisease managementdrug developmentdrugsframeworkstechnologiesviewpoints

Identifiers

PMID40743522
PMCPMC12355138

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.