Evidence mapPaperPMID 40744503Full record

ArticleClinical obesity2025

IMPROVE 2023: The 2nd International Meeting on Pathway-Related Obesity: Vision & Evidence.

Karine Clément, Erica L T van den Akker, Jesús Argente, Phil Beales, Metin Cetiner, Béatrice Dubern, Sadaf Farooqi, Aurélie Gouronc, Peter Kühnen, Johanne Le Beyec and 10 more

Abstract readConference Proceedings
In one paragraph

Article in Clinical obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Karine ClémentINSERM, Nutrition and Obesity: Systemic Approaches, NutriOmics, Research Unit, Sorbonne Université, Paris, France.
Erica L T van den AkkerDepartment of Paediatrics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Jesús ArgenteDepartment of Paediatrics and Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Research Institute La Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Phil BealesGenetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.
Metin CetinerDepartment of Paediatrics II, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Béatrice DubernDepartment of Nutrition and Paediatric Gastroenterology, CHU Trousseau, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.
Sadaf FarooqiInstitute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Aurélie GouroncLaboratoires de Diagnostic Génétique, Institut de Génétique Médicale d'Alsace, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Peter KühnenDepartment of Paediatric Endocrinology and Diabetology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Berlin, Berlin, Germany.
Johanne Le BeyecAssistance Publique-Hôpitaux de Paris, Sorbonne Université, Service de Biochimie Endocrinienne et Oncologique, Hôpital de la Pitié-Salpêtrière, Paris, France.
Louis LebretonDépartement de Biochimie, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
David MeekerRhythm Pharmaceuticals, Boston, Massachusetts, USA.
Hermann L MüllerDepartment of Paediatrics and Paediatric Hematology/Oncology, University Children's Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany.
Jean MullerLaboratoires de Diagnostic Génétique, Institut de Génétique Médicale d'Alsace, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Christine PoitouINSERM, Nutrition and Obesity: Systemic Approaches, NutriOmics, Research Unit, Sorbonne Université, Paris, France.
Patrick SleimanRhythm Pharmaceuticals, Boston, Massachusetts, USA.
Christian VaisseDepartment of Medicine, University of California, San Francisco, California, USA.
Martin WabitschDivision of Pediatric Endocrinology and Diabetes, Ulm University, Ulm, Germany.
Jacques YoungDepartment of Endocrinology and Reproductive Diseases, University Paris Saclay, Assistance Publique Hôpitaux de Paris, Bicêtre Hospital, Paris, France.
Hélène DollfusLaboratoire de Génétique Médicale, UMRS_1112, Institut de Génétique Médicale d'Alsace, INSERM-Université de Strasbourg, Strasbourg, France.

Funding

Rhythm Pharmaceuticals Inc
6 · The paper itself

Abstract

A total of 150 clinicians and researchers representing 19 countries came together in person and online to participate in the highly anticipated 2nd International Meeting on Pathway-Related Obesity: Vision & Evidence (IMPROVE), held on 13-15 December 2023 in Paris, France. Building on the success of the inaugural event in 2022, this gathering served as a pivotal platform for attendees to delve into the latest scientific and clinical developments in hyperphagia and early-onset obesity caused by rare melanocortin-4 receptor (MC4R) pathway disease. The central objective of the meeting was to explore the complexities of MC4R pathway-related diseases and generate opportunities for collaborative dialogue among delegates for the advancement of this field. The event unfolded across three distinct sessions, with a dedicated focus on monogenic MC4R pathway disease, Bardet-Biedl syndrome (BBS) and hypothalamic obesity, together with a discussion on the future of the field. Additionally, the agenda featured three insightful workshops designed to facilitate in-depth discussions. One workshop focused on the genetics of monogenic MC4R pathway diseases, another scrutinised the genetics of BBS and the final workshop examined patient management through the exploration of clinical cases. As we reflect on the wealth of information disseminated and the collaborative spirit that permeated the meeting, it becomes clear that IMPROVE 2023 was not merely an assembly of professionals; it was a forum where the future of research in rare MC4R pathway diseases and patient care took centre stage. Here, we encapsulate the key insights, discussions, and initiatives that emerged from this important meeting.

Indexed as

Bardet-Biedl SyndromeObesityReceptor, Melanocortin, Type 4HumansHyperphagiaMC4R protein, humanReceptor, Melanocortin, Type 4Bardet‐Biedl syndromehyperphagiaMC4R pathwaymonogenic disease

Identifiers

PMID40744503
PMCPMC12401656

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.