Observational studyAnnals of medicine2025
Trends and levels of the global, regional, and national burden of injuries from 1990 to 2021: findings from the global burden of disease study 2021.
Observational study in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Occupational therapy improves functional recovery and reduces delirium in critically ill adults with and without stroke: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- East Asia and high-income Asia Pacific burden of diabetes mellitus from 1990 to 2023.iScience · 2026Article
- Article
- Time series modeling to predict mortality rates and estimate years of life lost due to injuries in West Azerbaijan province, Iran, 2013-2024.BMC public health · 2026Observational
- Longitudinal trends and future projections of injury-related economic burden among middle-aged and older adults in China: analysis of CHARLS data 2011-2018.Health economics review · 2026Article
- Sesamol as a multifunctional antioxidant in tissue injury and repair: mechanistic insights and therapeutic perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- From molecular networks to precision therapeutics: the evolving landscape of trauma-induced coagulopathy.World journal of emergency surgery : WJES · 2026Review
- Association between sustained moderate hyperglycemia within first 48 hours and poor functional outcome after polytrauma: A retrospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Observational
- The Burdens of Idiopathic Developmental Intellectual Disability Attributable to Lead Exposure from 1990 to 2023 and a Projection to 2050 in the USA: Findings from the Global Burden of Disease Study 2023.Healthcare (Basel, Switzerland) · 2026Article
- Deep learning guided propofol ketamine dosing and inflammation trajectories in elderly burns.Frontiers in computational neuroscience · 2026Article
- Regional Statistics from 2023 Community-based Severe Trauma Surveillance in the Gyeongnam Region.Public health weekly report · 2026Article
- Efficacy and safety of Oliceridine versus Sufentanil in postoperative analgesia for burn skin grafting: a machine learning and SHAP-based cohort study.Frontiers in medicine · 2026Article
- Biofilm Formation on Indwelling Medical Devices: A Review of Health and Economic Implications.International journal of microbiology · 2026Review
- A comprehensive analysis of vitamin A deficiency in China from 1990 to 2021, examining temporal trends and demographic influences.Frontiers in nutrition · 2025Article
- Incidence, Mortality, and Premature Mortality From Neonatal Disorders in Eastern Sub-Saharan Africa, From 1990 to 2023.Sage open pediatricsArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesInjuries remain a major global public health challenge. This study aimed to analyze the global, regional, and national burden of injuries from 1990 to 2021 and project future trends to 2046, addressing a gap in long-term trend analyses and projections accounting for demographic shifts. PATIENTS/MATERIALS AND
methodsWe conducted an observational analysis using data from the Global Burden of Disease (GBD) Study 2021, covering 204 countries and territories. We extracted data on injury incidence, prevalence, mortality, and disability-adjusted life years (DALYs). Age-standardized rates (ASRs) were calculated. Temporal trends (1990-2021) were assessed using estimated annual percentage change (EAPC). Future burden (2022-2046) was projected using statistical modeling.
resultsGlobally, while absolute numbers of injury incidence, prevalence, deaths, and DALYs increased from 1990 to 2021, all corresponding ASRs declined significantly (EAPC: incidence - 0.96%, prevalence - 0.73%, mortality - 1.55%, and DALYs - 1.75%). Males consistently bore a greater burden than females (mortality ratio male:female = 2.41). Marked disparities existed: mortality rates in low Socio-demographic Index (SDI) regions were 2.5 times higher than in high SDI regions. Afghanistan, the Central African Republic, and Lesotho had the highest national mortality rates; Singapore, Spain, and Italy the lowest. Projections indicate rising absolute cases but declining ASRs through 2046.
conclusionDespite declining ASRs, the increasing absolute injury burden necessitates intensified prevention efforts. Targeted interventions are crucial to address persistent geographic, demographic (especially males), and socioeconomic (low SDI regions) disparities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.