Design of highly sensitive refractive index biosensor with cobalt-glass materials for detection of glucose concentration in blood.

Trupti Kamani, Shobhit K Patel, Sana Ben Khalifa, Saleh Chebaane, Om Prakash Kumar, Ishwar Bhiradi, Ammar Armghan

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Efficient and optimized blood cancer detection using engineered graphene-based silicon-TiN-silicon multilayered plasmonic sensor design with behaviour prediction using machine learning.Scientific reports · 2026
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7 authors.

Trupti KamaniDepartment of Physics, Marwadi University, Rajkot, 360003, India.

Shobhit K PatelDepartment of Computer Engineering, Marwadi University, Rajkot, 360003, India.

Sana Ben KhalifaDepartment of Physics, College of Science, Qassim University, P.O.Box 6644, Buraydah Almolaydah, 51452, Saudi Arabia.

Saleh ChebaaneDepartment of physics, College of Science, University of Ha'il, P.O.Box 2440, Ha'il, Saudi Arabia.

Om Prakash KumarDepartment of Electronics and Communication Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India.

Ishwar BhiradiDepartment of Mechatronics, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India. ishwar.bhiradi@manipal.edu.

Ammar ArmghanDepartment of Electrical Engineering, College of Engineering, Jouf University, Sakaka, 72388, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes represents a conceivably fatal condition that occurs because of elevated blood glucose levels. The surface plasmon resonance (SPR) biosensor has emerged as currently the most sophisticated method for determining glucose levels. The blood glucose biosensor performance is determined by the refraction coefficient of the substance containing glucose in the form of molecules. In this study, we have offered Hollow-Ring Cubic-Structured Refractive Index Biosensor (HRCSRIB) for monitoring glucose levels in blood from normal concentrations of 165 to 180 (mg/dL) in compared to diabetic glucose concentrations of 182, 205, 220, 240, 255, 289, 255 (mg/dL). This biosensor detects variations in the refractive index of urine, which correlate with changes in blood glucose concentration. The presented biosensing technology uses cobalt compounds and their unique structure to analyze blood glucose levels by measuring the urine refractive value. The study of various parameters associated with geometrical shape dimensions has been also represented. This offered biosensor has an exceptional sensitivity with 1750 nm/RIU, and a detection limit of 0.000410. The exceptional value of the quality factor, as well as the figure of merit value, is 1670.07 nm/RIU for 182 mg/dL and 1241.13 for 205-289 mg/dL respectively. The best transmittance response of 6%, 9%, 4%, and 32% has been obtained. The aforementioned sensor's distinctive characteristics facilitate its biomedical applications as an optical on-chip sensor that monitors level of glucose.

Indexed as

Biosensing TechniquesBlood GlucoseCobaltGlassRefractometryDiabetes MellitusHumansLimit of DetectionSurface Plasmon ResonanceBlood GlucoseCobaltBiomedical applicationsBiosensing techniquesCobalt compoundsGlucose concentrationHigh sensitivityParametric analysisRefractive index biosensorSDG 12 (Responsible consumption and production)SDG 3 (Good health and Well-Being)SDG 9 (Industry, innovation and infrastructure)

Identifiers

PMID40744990

DOI10.1038/s41598-025-13498-y

PMCPMC12313932

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