Evidence map›Paper›PMID 40745037›Full record

SynthesisJournal of neurology2025

Intra-arterial thrombolysis as rescue therapy for incomplete reperfusion following thrombectomy: a meta-analysis.

Kangjia Song, Shuang Qi, Zhenni Guo, Mingchao Shi, Chao Li, Zan Wang, Shouchun Wang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kangjia Song *Department of Neurology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, Jilin, China.
Shuang Qi *Department of Neurology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, Jilin, China.
Zhenni GuoDepartment of Neurology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, Jilin, China.
Mingchao ShiDepartment of Neurology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, Jilin, China.
Chao LiDepartment of Neurology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, Jilin, China. lichao1983@jlu.edu.cn.
Zan WangDepartment of Neurology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, Jilin, China. wangzan@jlu.edu.cn.
Shouchun WangDepartment of Neurology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, Jilin, China. WSC@jlu.edu.cn.ORCID http://orcid.org/0000-0002-0714-4299

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeMechanical thrombectomy (MT) is a primary treatment for acute ischemic stroke caused by large vessel occlusion. However, incomplete reperfusion is common and leads to poorer patient outcomes. Intra-arterial thrombolysis (IAT) is a potential rescue therapy, but its efficacy and safety remain controversial.

methodsA comprehensive literature search was performed across PubMed, Scopus, Web of Science, and Cochrane Library up to January 2025. The search included terms related to stroke, thrombectomy, thrombolysis, and intra-arterial. Studies comparing IAT as rescue therapy following MT with MT alone in patients with incomplete reperfusion were included. The primary outcome was functional independence (modified Rankin Scale [mRS] score of 0-2 at 90 days). Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using a random-effects model. This meta-analysis followed PRISMA guidelines and was registered with PROSPERO (CRD420251063825).

resultsSeven studies, totaling 1893 patients (374 in MT + IAT; 1519 in MT alone) were included. Pooled analysis indicated that IAT as a rescue therapy was associated with significantly higher odds of functional dependence at 90 days (OR 1.40, 95% CI 1.06-1.83; p = 0.017) and lower 90-day mortality (OR 0.69, 95% CI 0.49-0.98; p = 0.036). There was no statistically significant increase in the risk of intracranial hemorrhage (OR 0.72, 95% CI 0.46-1.11; p = 0.132) or symptomatic intracranial hemorrhage (OR 1.10, 95% CI 0.59-2.03; p = 0.768) associated with IAT.

conclusionsIn patients with incomplete reperfusion after MT, IAT as rescue therapy improved functional outcomes and reduced mortality within 90 days, without increasing the risk of ICH or sICH.

Indexed as

Fibrinolytic AgentsIschemic StrokeReperfusionThrombectomyThrombolytic TherapyHumansFibrinolytic AgentsAcute ischemic strokeIntracranial hemorrhageMechanical thrombectomyMeta-analysisThrombolysis

Identifiers

PMID40745037

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.