ArticlePlant molecular biology2025
Unveiling transcriptional regulation underpinning chilling and frost stress response in Trans-Himalayan Hippophae tibetana L.
Article in Plant molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Hippophae tibetana is an enigmatic least explored Seabuckthorn species, with exceptional adaptability to sub-zero temperatures in Trans-Himalayan region. This study integrates physiological and transcriptional profiling to understand its unique cold stress resilience. The physiological assessment including chlorophyll content, relative water content, and electrolyte leakage were least affected during the early response (ER) of cold stress as compared to prolonged (PR) and freeze response (FR), which was effectively restored during the recovery phase (RR). Genome-guided de novo assembly yielded 25,176 high-quality unigenes (N50: 2195 bp; BUSCO: 92.9%), with 75.9% functionally annotated using NCBI-nr, Araport11, SwissProt, COG, KEGG, and Pfam databases. Clustering of differentially expressed unigenes revealed ER (4467 DEGs) and RR (4478) grouped distinctly from PR (14,150) and FR (14,528), underscoring significantly heightened transcriptional reprogramming during PR/FR compared to ER/RR. Furthermore, the integration of transcriptional interactome network with GO and KEGG enrichment highlighted ICE1-CBF regulatory network with significant upregulation of Inducer of CBF Expression (ICE1), Cold receptive protein kinase (CRPK1), anti-freeze proteins (AFPs), and pathways like jasmonic acid signaling, carbohydrate metabolism, and membrane stabilization as key to cold tolerance during PR and FR phases. The current study advances our understanding of cold stress resilience in H. tibetana, elucidating its adaptive mechanisms in extreme Trans-Himalayan environments. The comprehensive genomic resources and key candidates identified here may provide a foundation for discovering cold tolerance-associated genome-wide variations in priority crops and plantation species.
Indexed as
Identifiers
40745105What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.