Evidence map›Paper›PMID 40745191›Full record

ArticleScientific reports2025

Maternal parity modifies the association of birthweight polygenic score with fetal growth.

Prabhavi Wijesiriwardhana, Tesfa Dejenie Habtewold, Guisong Wang, Jessica L Gleason, Ronald J Wapner, Katherine L Grantz, Fasil Tekola-Ayele

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Prabhavi WijesiriwardhanaEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892-7004, USA.
Tesfa Dejenie HabtewoldEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892-7004, USA.
Guisong WangThe Prospective Group (TPG), Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892-7004, USA.
Jessica L GleasonEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892-7004, USA.
Ronald J WapnerDepartment of Obstetrics and Gynecology, Columbia University, New York, NY, 10032, USA.
Katherine L GrantzEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892-7004, USA.
Fasil Tekola-AyeleEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892-7004, USA. ayeleft@mail.nih.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low birthweight is more common among children born to nulliparas (women with no prior pregnancy lasting ≥20 weeks of gestation) compared to those born to multiparas (women with one or more prior pregnancies lasting ≥20 weeks). We investigated whether parity modifies the association of maternal genetic risk score (mGRS) of maternal birthweight-reducing genetic variants with fetal size and weekly growth pace (i.e., change in fetal size over a 1-week gestational age interval) at gestational weeks 10-40 in two multi-ancestral cohorts of pregnant women. mGRS, derived from previously identified birthweight-reducing maternal variants was tested for association with fetal size and weekly growth pace using linear regression adjusted for fetal sex and top 10 genetic principal components. Among nulliparas, but not among multiparas, higher birthweight-reducing mGRS was associated with lower fetal size and slower weekly growth pace as measured by fetal weight, humerus and femur lengths, and abdominal and head circumferences beginning from gestational week 11. The findings suggest that the maternal genetic factors target major physiological changes at the first pregnancy that get less profound with multi-parity. Considering parity as a biological variable may facilitate the precision of identifying sensitive intrauterine periods and interventions for pregnancy outcomes using genomics.

Indexed as

Birth WeightFetal DevelopmentMultifactorial InheritanceParityAdultFemaleGestational AgeHumansInfant, NewbornMalePolymorphism, Single NucleotidePregnancyBirthweightFetal growthMaternal genetic riskMulti-ancestralParityPregnancy

Identifiers

PMID40745191
PMCPMC12313924

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.