Evidence map›Paper›PMID 40745496›Full record

Trial reportEuropean journal of applied physiology2026

Influence of exogenous ketosis on spontaneous cardiovagal baroreflex gain and blood pressure responses to isometric handgrip in individuals with metabolic syndrome: a placebo-controlled pilot study.

Jon Stavres, Ryan S Aultman, Caleb F Brandner, Anabelle Vallecillo-Bustos, Abby T Compton, Sydney H Swafford, Ta'Quoris A Newsome, Austin J Graybeal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05651243 (Non-pharmacological Treatments for Obesity), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05651243 nacompletednot on this map

Non-pharmacological Treatments for Obesity: Leveraging the Appetite Suppressive Effects of Hyperketonemia Through Exogenous Ketone Ingestion to Treat Obesity, Insulin Resistance, and Cognition

TypeinterventionalSponsorUniversity of Southern MississippiRan2022 to 2023Enrolled20ConditionsMetabolic SyndromeArmsKetone Ester Supplement, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jon StavresSchool of Kinesiology and Nutrition, College of Education and Human Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA. jonathon.stavres@usm.edu.ORCID http://orcid.org/0000-0003-0564-7252
Ryan S AultmanSchool of Health Sciences, Kent State University, Kent, OH, USA.
Caleb F BrandnerDepartment of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA.
Anabelle Vallecillo-BustosSchool of Kinesiology and Nutrition, College of Education and Human Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Abby T ComptonSchool of Kinesiology and Nutrition, College of Education and Human Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Sydney H SwaffordSchool of Kinesiology and Nutrition, College of Education and Human Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Ta'Quoris A NewsomeSchool of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Austin J GraybealSchool of Kinesiology and Nutrition, College of Education and Human Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.

Funding

Tracking and Evaluation CoreU54GM115428 · UNIVERSITY OF MISSISSIPPI MED CTR · 2025 to 2025
$3.6M
NIGMS NIH HHS U54GM115428University of Southern Mississippi Start-up Funds
6 · The paper itself

Abstract

backgroundPrior studies have shown that ingestion of exogenous ketone esters (KE) significantly increases cerebral blood flow and skeletal muscle oxygenation in humans. This pilot study tested the hypothesis that KE may also lower exercise pressor responses and improve cardiovagal baroreflex sensitivity (cBRS) in individuals with metabolic syndrome (MetS).

methodsTwenty individuals (ten with MetS and ten matched controls) completed a three visit, single-blind, placebo-controlled, matched-pairs pilot study involving a cardiometabolic prescreening and two randomized experimental trials. In the experimental trials, cardiovagal baroreflex sensitivity (cBRS), heart rate variability (HRV), and exercise pressor responses to 2 min of isometric handgrip exercise (HG) were evaluated at baseline, and during a 105-min period following ingestion of a commercially available KE or a taste- and volume-matched placebo.

resultsMain effects of condition and group by time interactions were observed for BP responses to HG (all p ≤ 0.050). The main effect of condition was explained by lower blood pressure values during HG in the KE trial compared to the placebo trial. The cBRS of all sequences (cBRS

conclusionsThis study provides preliminary evidence that acute exogenous ketosis may reduce blood pressure responses to acute exercise and attenuate spontaneous baroreflex gain in individuals with MetS (NCT05651243).

Indexed as

BaroreflexBlood PressureHand StrengthMetabolic SyndromeAdultExerciseFemaleHeart RateHumansMaleMiddle AgedPilot ProjectsSingle-Blind MethodBlood pressureCardiometabolic diseaseHeart rate variabilityHyperketonemiaKetogenic dietKetones

Identifiers

PMID40745496

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.