ArticleBMC research notes2025
The effect of two types of exercise conditioning on hypothalamic corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GNRH) gene expression response to acute noise stress in rats.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Meteorin-like protein may be a mediator of exercise-related reproductive disorders in female rats.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effect of two types of exercise on the hypothalamic expression of CRH and GnRH genes in response to acute noise stress in young rats. 42 male Wistar rats were divided into 7 groups including control (Con), Control Time (CT), acute noise stress (S), Moderate-intensity Continuous Training (MCT), High-Intensity Interval Training (HIIT), MCT + noise stress (MS), and HIIT + noise stress (HS). Exercise raining was performed for eight weeks. Noise stress was induced for one session. Hippocampus samples were taken 48 h following eight weeks in exercise training groups (MCT and HIIT) as well as CT and just after noise stress in related groups (S, HS, and MS). One-way analysis of variance (ANOVA) was used to compare the groups. CRH expression was significantly higher in the HIIT group while was significantly lower in the MCT group compared to the CT group (P = 0.0001). GnRH expression was significantly lower in the HIIT group than the MCT group; it was significantly higher in MCT group than the CT group (P = 0.0001). CRH expression increased in S group (P = 0.0001); it was significantly lower in HS and MS groups than in S group. CRH expression was significantly higher while, GnRH expression was significantly lower in the MS group compared to MCT group (P = 0.0001). So, HIIT inhibited GnRH and increased CRH while MCT increased GnRH and inhibited CRH gene expression. HIIT and MCT training, in that order, were effective in reducing the effects of noise stress.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.