Evidence map›Paper›PMID 40745950›Full record

ReviewMedicinal research reviews2026

Digital Therapeutics for Alzheimer's and Parkinson's Diseases: Current Trends and Future Perspectives.

Yoo Joo Jeong, Hyun-Ju Lee, Jun-Su Kim, Seung-Jae Kim, Unhui Jo, Jin Yeop Park, Su Jin Jun, Won Seok Lee, Mingoo Song, Donggii Kim and 3 more

Abstract readReview
In one paragraph

Review in Medicinal research reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yoo Joo JeongDepartment of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0009-0009-6598-3865
Hyun-Ju LeeDepartment of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0000-0002-4532-6448
Jun-Su KimAI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0009-0001-1191-6079
Seung-Jae KimAI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0000-0001-9955-4254
Unhui JoAI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0000-0001-7309-4675
Jin Yeop ParkAI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0009-0007-3448-3783
Su Jin JunAI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0009-0005-3617-0348
Won Seok LeeAI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0000-0002-1606-6958
Mingoo SongStoneLab Inc., Daejeon, Republic of Korea.
Donggii KimDigital Health Division, Daegu Digital Innovation Promotion Agency, Daegu, Republic of Korea.ORCID 0009-0007-1044-9249
Gyoujin ChoDepartment of Biophysics, Institute of Quantum Biology, Sungkyunkwan University, Suwon, Republic of Korea.ORCID 0000-0002-2451-5426
Jeong-Heon SongAI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0009-0000-5443-1066
Hyang-Sook HoeDepartment of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0000-0001-8877-8594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD), which are characterized by the accumulation of misfolded protein aggregates and cognitive/motor dysfunction, are the most prevalent neurodegenerative diseases (NDDs). Despite strategic investigations aimed at augmenting the pharmaceutical pipeline, available drugs for AD and PD merely slow disease progression without curing or treating the underlying pathology. Recent technological advances have given rise to digital therapeutics (DTx): software systems that aim to prevent, cure, and manage specific diseases, including NDDs. For AD and PD, the majority of DTx focus on enhancing cognitive/executive function and motor-related functions, respectively. In this review, we describe the status of therapeutic development for AD and PD, as well as the characteristics and status of DTx targeting these NDDs. In addition, we address the limitations and challenges of DTx and their implications for the treatment of AD and PD. Ultimately, this review provides insights into the potential of DTx as a therapeutic modality and future directions for the development of DTx targeting AD and PD.

Indexed as

Alzheimer DiseaseDigital HealthParkinson DiseaseSoftwareClinical Trials as TopicCognitionExecutive FunctionHumansMachine LearningMotor ActivityVirtual Reality Exposure TherapyAlzheimer's diseasedigital therapeuticsneurodegenerative diseasesParkinson's diseasepharmacotherapeutics

Identifiers

PMID40745950
PMCPMC12673471

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.