Evidence map›Paper›PMID 40746442›Full record

ArticleStem cells international2025

ipRGCs Sensitive Blue Light Exposure Promotes the Robustness of Circadian and Neural Stem Cells in Sleep Deprived Conditions.

Zhaoting Bu, Xiaotong Li, Jinyu Shi, Qiaozhen Qin, Heyang Zhang, Yuanrong Qiu, Lingyu Zhang, Yifei Tan, Hanping Shi, Xiaoxia Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhaoting BuDepartment of Neuroimmunology and Antibody Engineering, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID https://orcid.org/0000-0002-6289-1385
Xiaotong LiDepartment of Neuroimmunology and Antibody Engineering, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID https://orcid.org/0009-0001-9361-9077
Jinyu ShiDepartment of Neuroimmunology and Antibody Engineering, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID https://orcid.org/0000-0002-7646-4632
Qiaozhen QinDepartment of Neuroimmunology and Antibody Engineering, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID https://orcid.org/0009-0000-3164-7139
Heyang ZhangDepartment of Neuroimmunology and Antibody Engineering, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID https://orcid.org/0000-0002-6047-6874
Yuanrong QiuDepartment of Medical Sciences, Jishou University, Jishou 416000, Hunan, China.ORCID https://orcid.org/0009-0006-8077-0786
Lingyu ZhangDepartment of Neuroimmunology and Antibody Engineering, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID https://orcid.org/0009-0007-3639-133X
Yifei TanDepartment of Neuroimmunology and Antibody Engineering, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID https://orcid.org/0009-0006-7169-0223
Hanping ShiDepartment of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.ORCID https://orcid.org/0000-0003-4514-8693
Xiaoxia JiangDepartment of Neuroimmunology and Antibody Engineering, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID https://orcid.org/0000-0003-1401-9653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian rhythm abnormalities due to sleep deprivation (SD) may promote the development of emotional and cognitive disorders. Though light therapies have been employed to treat circadian disorders, the exact treatments and their underlying biology are still unclear. Our study aimed to investigate the effects of intrinsically photosensitive retinal ganglion cells (ipRGCs) sensitive 480 nm blue light on circadian rhythms affecting emotional and cognitive behaviors and the expression of neural stem cells (NSCs) stemness genes. In this study, we demonstrate that for mice with acute SD for 24 h, exposure to ipRGCs sensitive 480 nm blue light at ~ 1300 lux for 30 min at 8:00 a.m. and 8:00 p.m. improves the stability of disrupted clock genes, increases nocturnal activity, reduces anxiety-like behaviors, and enhances cognitive abilities. Furthermore, 480 nm blue light exposure reduces fluctuations in NSCs stemness gene expression induced by SD, potentially through its effect on enhancing the amplitude of suprachiasmatic nucleus (SCN) circadian oscillations. These findings may provide novel strategy for alleviating rotating circadian rhythm-related anxiety and learning and cognitive obstruction.

Indexed as

blue lightcircadian rhythmneural stem cellssleep deprivation

Identifiers

PMID40746442
PMCPMC12313382

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.