ArticleFrontiers in endocrinology2025
Gene signatures associated with exosomes as diagnostic markers of postpartum depression and their role in immune infiltration.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Relationship Between Trace Elements and Depression.Nutrients · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postpartum depression (PPD) is a significant mental health challenge for new mothers, with diverse and unclear causes. Exosomes significantly contribute to the pathogenesis, identification, treatment outcome determination, and intervention of PPD. However, the functions of exosome-related genes (ERGs) in PPD remain to be fully elucidated. This study examines the potential impact of ERGs on PPD and develops a set of diagnostic tools based on them. Methods: We acquired and prepared several gene expression datasets from the Gene Expression Omnibus (GEO). Our analysis focused on genes that closely interact with the extracellular matrix. Using advanced techniques, including the Results: We identified 44 exosome-related differentially expressed genes (ERDEGs) that play key roles in synaptic signal transmission, hormone fluctuations, and inflammatory responses. Ten genes, including Conclusions: ERDEGs significantly contribute to PPD occurrence. Our diagnostic model demonstrated high accuracy and potential for use in medical practice. Future research with larger samples is warranted to validate these conclusions and identify effective targets that may affect these pathways during treatment to improve the therapeutic effect.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.