Evidence map›Paper›PMID 40747620›Full record

ArticleACS sensors2025

Tracking Intracellular Labile Iron with a Genetically Encoded Fluorescent Reporter System Based on Protein Stability.

Ali Akyol, Şeyma Çimen, Benjamin Gottschalk, Yusuf C Erdoğan, Anna Lischnig, Amy Barton Alston, Reinaldo Digigow, Beat Flühmann, Emrah Eroğlu, Wolfgang F Graier and 1 more

Abstract read
In one paragraph

Article in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ali AkyolGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.ORCID 0000-0003-2119-2390
Şeyma ÇimenRegenerative and Restorative Medicine Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, 34810 Istanbul, Turkey.ORCID 0000-0003-4625-106X
Benjamin GottschalkGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.
Yusuf C ErdoğanGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.
Anna LischnigGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.
Amy Barton AlstonCSL Vifor Ltd., Redwood City, California 94063, United States.
Reinaldo DigigowCSL Vifor Ltd., Flughofstrasse 61, 8152 Opfikon, Switzerland.
Beat FlühmannCSL Vifor Ltd., Flughofstrasse 61, 8152 Opfikon, Switzerland.
Emrah EroğluRegenerative and Restorative Medicine Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, 34810 Istanbul, Turkey.ORCID 0000-0002-9373-0808
Wolfgang F GraierGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.ORCID 0000-0003-1871-3298
Roland MalliCenter for Medical Research, CF Bioimaging, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.ORCID 0000-0001-6327-8729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we developed IronFist, a genetically encoded fluorescent reporter that enables dynamic tracking of labile ferrous ions (Fe

Indexed as

Fluorescent DyesIronLuminescent ProteinsGreen Fluorescent ProteinsHumansProtein StabilityRed Fluorescent ProteinFluorescent DyesGreen Fluorescent ProteinsIronLuminescent ProteinsRed Fluorescent Proteinfluorescence microscopyHr domainiron carbohydrate nanoparticlesiron-dependent degroniron reporterlabile iron pool

Identifiers

PMID40747620
PMCPMC12379171

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.