Evidence map›Paper›PMID 40747680›Full record

ArticleOncoimmunology2025

Patient-derived ovarian cancer models demonstrate the influence of tumor-associated macrophages on therapeutic response.

Parisa Nikeghbal, Danielle Burke, Dalet Armijo, Samuel Aldarondo-Quiñones, Diane S Lidke, Mara P Steinkamp

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Parisa NikeghbalDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Danielle BurkeDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Dalet ArmijoDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Samuel Aldarondo-QuiñonesDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Diane S LidkeDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Mara P SteinkampDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.ORCID 0000-0003-1226-9325

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
NCI NIH HHS P30 CA118100
6 · The paper itself

Abstract

While most ovarian cancer (OC) patients respond to front-line platinum/taxane chemotherapy and surgical debulking, the majority will develop platinum-resistance and recur. Our study investigated how tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) affect chemotherapy outcomes using OC patient-derived organoids and humanized patient-derived xenografts (huPDX).

Indexed as

Ovarian NeoplasmsTumor-Associated MacrophagesAnimalsCell Line, TumorDrug Resistance, NeoplasmFemaleHumansMiceOrganoidsPaclitaxelTumor MicroenvironmentXenograft Model Antitumor AssaysPaclitaxelChemotherapyhumanized PDXimmunotherapyorganoidsovarian cancerpatient-derived modelstumor-associated macrophagestumor microenvironment

Identifiers

PMID40747680
PMCPMC12320822

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.