Evidence map›Paper›PMID 40747803›Full record

ArticleThe oncologist2025

A blueprint for creating an early-onset colorectal cancer program based on experiences from 7 clinical centers across the United States and Canada.

Kimmie Ng, Cathy Eng, Petra Wildgoose, Y Nancy You, Andrea Cercek, Aparna Parikh, David Liska, Uditi Ratti, Barry D Stein

Abstract read
In one paragraph

Article in The oncologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Emerging trends in the global burden of colorectal cancer.Nature reviews. Clinical oncology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kimmie NgYoung-Onset Colorectal Cancer Center, Dana-Farber Cancer Institute, Boston, MA, United States.ORCID 0000-0003-0631-1494
Cathy EngYoung Adult Cancers Program, Vanderbilt-Ingram Cancer Center, Nashville, TN, United States.ORCID 0000-0003-2335-0612
Petra WildgooseYoung Adult Colorectal Cancer Program, Odette Cancer Centre, Toronto, Ontario, Canada.
Y Nancy YouYoung-Onset Colorectal Cancer Program; Professor, Department of Colon & Rectal Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.ORCID 0000-0002-5294-288X
Andrea CercekCenter for Young Onset Colorectal and Gastrointestinal Cancers, Memorial Sloan Kettering Cancer Center, New York, NY, United States.ORCID 0000-0002-5054-8192
Aparna ParikhDepartment of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-5245-7841
David LiskaDepartment of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, United States.ORCID 0000-0002-8632-6065
Uditi RattiFrazer Health Authority, Surrey, British Colombia, Canada.
Barry D SteinColorectal Cancer Canada, Montreal, Quebec, Canada.ORCID 0009-0007-3048-5124

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Novel randomized controlled trials of vitamin D supplementation in patients with colorectal cancer: Impact on survival and biologyR01CA205406 · NCI · DANA-FARBER CANCER INST · PI Kimmie Ng · 2017 to 2026
$4.9M
Colorectal Cancer CanadaNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA205406
6 · The paper itself

Abstract

backgroundThe incidence of individuals diagnosed with colorectal cancer under the age of 50, often referred to as early-onset colorectal cancer (EOCRC), has risen worldwide. The EOCRC patients have unique needs; however, there are no clear guidelines on how to address them. The objective of the present study was to propose a blueprint for EOCRC program development and implementation. MATERIALS AND

methodsA consensual qualitative design was used to frame the present study. Seven leaders of North American EOCRC centers were invited to devise a stepwise blueprint for developing and implementing EOCRC programs. Discussions were transcribed and conceptually organized into a framework. An analysis of documents detailing and describing the services offered within each center was also conducted.

resultsThe analysis was organized around 2 domains: (1) the rationale underlying the creation of EOCRC programs, and (2) the lessons learned from developing and implementing EOCRC programs. Participants agreed that as the EOCRC programs represent innovative initiatives, a program manager who closely monitors the program is core to successful implementation.

conclusionsThis study outlines a 10-step actionable guideline for developing and implementing EOCRC programs aiming at addressing the unmet needs of this growing population.

Indexed as

Colorectal NeoplasmsAge of OnsetCanadaFemaleHumansMaleMiddle AgedProgram DevelopmentUnited Statescare deliverycolon cancercolorectal cancerearly-onset colorectal cancerearly-onset colorectal cancer programpractical guiderectal cancer

Identifiers

PMID40747803
PMCPMC13223743

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.