ReviewMolecular neurobiology2025
BDNF Signaling in Glutamatergic Neurons During Long-Term Potentiation (LTP): A Spatio-Temporal Exploration of Events.
Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Closed-Loop Neuromodulation for Brain Fatigue: From Real-Time Biomarkers to Adaptive Intervention.International journal of molecular sciences · 2026Review
- Review
- Calcineurin/NFAT signaling in the temporal integration of Ca²⁺ stress in neurodegeneration.Cell death discovery · 2026Review
- Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- BDNF-TrκB-PLCγ signaling drives BPA-induced mechanical allodynia through activating mechanosensitive Piezo2 channels.Cell & bioscience · 2026Article
- Enviromimetics: From exercise mimetics to cognitomimetics in the quest for enhanced brain health and cognition.The Journal of physiology · 2026Review
- Dysregulated mRNA Translation in Alzheimer's Disease: Mechanisms, Therapeutic Opportunities, and Challenges for Clinical Translation.Clinical interventions in aging · 2026Review
- BDNF-amyloid-Frontiers in molecular neuroscience · 2026Review
- From arthritis to central sensitization: targeting the neuro-immune axis via microglial modulation in acupuncture treatment for Juvenile Idiopathic Arthritis-associated pain.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term potentiation (LTP), a cellular mechanism underlying learning and memory, progresses through three stages-initial, early, and late-each characterized by distinct molecular events that contribute to memory consolidation. What might bind them together is, on the molecular level, the release of brain-derived neurotrophic factor (BDNF) from excitatory neurons. Excitatory neurons release glutamate and, in addition, if stimulated in the right manner, also secrete BDNF. Key signaling pathways mediating BDNF's effects in the process from early to late memory processes include the MAPK/ERK, PI3K/Akt, and PLCγ/IP3 cascades. Notably, glutamate signaling activates PLCβ/IP3, PI3K/Akt, and MAPK/ERK pathways, reinforcing synaptic strength. This review explores the spatio-temporal activation of these pathways across LTP stages, emphasizing the interplay between BDNF and glutamate in shaping the excitatory synaptic plasticity. By mapping these molecular events, we aim to provide a comprehensive framework for understanding how BDNF-driven signaling contributes to neuroplasticity and memory formation.
Indexed as
Identifiers
40748428What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.