ArticleCurrent microbiology2025
Alterations in the Gut Microbiota and Metabolite Profiles of Lung Cancer Patients.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide. The gut microbiota is known to be involved in the occurrence and development of a variety of cancers, but the role of gut microbiota in lung cancer remains unclear. Here, we selected fecal samples of lung cancer patients and healthy people for 16S rRNA high-throughput sequencing and untargeted metabolomics analysis, respectively. The results showed that Actinobacteria, Proteobacteria, Patescibacteria, Cyanobacteria and Verrucomicrobiota were enriched in the LC; And the interaction between bacteria in the LC was more complicated than that in the NC. ROC showed that Actinobacteriota, Bacteroidota, Verrucomicrobiota and 7 kinds of bacteria at the genus have a better resolution for LC There are 82 kinds of metabolites that were different between NC and LC, mainly lipid metabolism molecules KEGG analysis indicated that Glycerophospholipid metabolism and alpha-Linolenic acid metabolism may be different in the LC and NC. ROC showed that 15 kinds of metabolites had a better classification effect on LC and NC; And we found that the correlation between metabolites in NC was higher than that in LC. This article pointed out the direction for follow-up research on its role in the occurrence and development of lung cancer.
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