Evidence map›Paper›PMID 40748720›Full record

ReviewPhysiology (Bethesda, Md.)2026

Brain Capillary Ion Channels: Physiology and Channelopathies.

Osama F Harraz, Ahmed M Hashad

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. PIPProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Osama F HarrazDepartment of Pharmacology, Larner College of Medicine, Vermont Center for Cardiovascular and Brain HealthUniversity of Vermont Burlington Vermont.ORCID 0000-0003-2061-1100
Ahmed M HashadDepartment of Pharmacology, Larner College of Medicine, Vermont Center for Cardiovascular and Brain HealthUniversity of Vermont Burlington Vermont.

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Diego Adrianzen Herrera · 2020 to 2026
$17.4M
Endothelial Piezo1 channel and cerebral blood flow controlR01HL169681 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Osama F Harraz · 2023 to 2026
$2.3M
Brain capillary Piezo1 ion channels and blood flow regulation in Alzheimer’s DiseaseR21AG082193 · NIA · UNIVERSITY OF MIAMI CORAL GABLES · PI BRACKO, OLIVER, HARRAZ, OSAMA F · 2023 to 2024
$434k
American Heart Association (AHA) 20CDA35310097American Heart Association-American Stroke Association 20CDA35310097 - OSAMA HARRAZChan Zuckerberg Initiative (CZI) DAFHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL169681HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM135007HHS | NIH | National Institute on Aging (NIA) R21AG082193NHLBI NIH HHS R01 HL169681NIA NIH HHS R21 AG082193NIGMS NIH HHS P20 GM135007Silicon Valley Community Foundation (SVCF) 2024-338506UVM | Larner College of Medicine, University of Vermont (LCOM)UVM | LCOM | Cardiovascular Research Institute of Vermont, Larner College of Medicine, University of Vermont (CVRI)UVM | LCOM | Cardiovascular Research Institute of Vermont, Larner College of Medicine, University of Vermont (CVRI) Bloomfield ProfessorshipUVM | Totman Medical Research Trust, University of Vermont
6 · The paper itself

Abstract

The brain relies on an intricate vascular network to deliver oxygen and nutrients through functional hyperemia, a process critical for matching blood flow to neuronal activity. This review explores the roles of ion channels in brain capillary endothelial cells and pericytes, focusing on their contributions to neurovascular coupling. Key endothelial ion channels, including Kir2.1, K

Indexed as

BrainCapillariesChannelopathiesIon ChannelsAnimalsCerebrovascular CirculationEndothelial CellsHumansNeurovascular CouplingPericytesIon Channelsbrain capillariescerebral blood flowendothelial cellsion channelspericytes

Identifiers

PMID40748720
PMCPMC12378794

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.