Evidence map›Paper›PMID 40749324›Full record

ReviewDNA repair2025

Cytosolic DNA and intracellular Ca

Shan Li, Hsiang-Ting Lu, Zhongsheng You

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in DNA repair, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shan LiZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China.
Hsiang-Ting LuDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zhongsheng YouDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: zyou@wustl.edu.

Funding

Dual Role of TRPV2 in the STING-mediated innate immune responseU01AI182074 · WASHINGTON UNIVERSITY · 2025 to 2025
$2.1M
Molecular mechanisms of DNA damage signaling and repairR01GM098535 · WASHINGTON UNIVERSITY · 2025 to 2025
$330k
NIAID NIH HHS U01 AI182074NIGMS NIH HHS R01 GM098535
6 · The paper itself

Abstract

Maintaining genome stability during DNA replication is a critical cellular challenge. Various surveillance and repair mechanisms have evolved to cope with replication stress, which can be caused by environmental insults, metabolic byproducts, complex DNA structures in the genome, and replication-transcription conflicts. This perspective highlights a newly identified cytosolic DNA/Ca

Indexed as

CalciumCytosolDNADNA ReplicationGenomic InstabilityAnimalsHumansSignal TransductionCalciumDNAAMPKCaMKK2cGAS/STINGCytosolic DNAEXO1Fork protectionIntracellular Ca(2+)Replication stressTRPV2

Identifiers

PMID40749324
PMCPMC13069576

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.